FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046028648> ?p ?o ?g. }

• W2046028648 endingPage "4192" @default.
• W2046028648 startingPage "4185" @default.
• W2046028648 abstract "A bradykinin analogue (H-Arg-Pro-Pro-Gly-Phe-Ser-D-BT-Arg-OH, 3) in which the Pro-Phe dipeptide was replaced by the (3S)[amino]-5-(carbonylmethyl)-2,3-dihydro-1, 5-benzothiazepin-4(5H)-one (D-BT) moiety has been synthesized. The same modification was performed on the potent bradykinin B(2) receptor antagonist HOE 140 (H-D-Arg-Arg-Pro-Hyp-Gly-Thi-Ser-D-Tic-Oic-Arg-OH), in which the -D-Tic-Oic- moiety was replaced by D-BT to yield H-D-Arg-Arg-Pro-Hyp-Gly-Thi-Ser-D-BT-Arg-OH, 1 (JMV1116). These compounds were examined in vitro for their binding affinity toward bradykinin B(1) and B(2) receptors as well as for their ability to interfere with bradykinin-induced contraction of both human umbilical vein and rat uterus. The two compounds 3 and 1 competed with [(3)H]bradykinin binding to the human cloned B(2) receptor giving K(i) values of 13 +/- 2 and 0.7 +/- 0.1 nM, respectively. Unexpectedly, both compounds were full bradykinin B(2) receptor agonists on the human umbilical vein (pD(2) = 6.60 +/- 0.07 for 3 and 6.80 +/- 0.08 for 1) and rat uterus (pD(2) = 7.20 +/- 0.09 for 3 and 7.50 +/- 0.09 for 1) preparations with the same efficacy as bradykinin. In addition 1 induced a concentration-dependent phosphoinositide production in CHO cells expressing the human cloned B(2) receptor. These data provide evidence for a bioactive conformation of bradykinin constrained at the dipeptide Pro-Phe." @default.
• W2046028648 created "2016-06-24" @default.
• W2046028648 creator A5010082819 @default.
• W2046028648 creator A5030232036 @default.
• W2046028648 creator A5045844512 @default.
• W2046028648 creator A5045906192 @default.
• W2046028648 creator A5052978566 @default.
• W2046028648 creator A5059138865 @default.
• W2046028648 creator A5061913955 @default.
• W2046028648 creator A5068275277 @default.
• W2046028648 creator A5072843336 @default.
• W2046028648 creator A5080510828 @default.
• W2046028648 date "1999-09-21" @default.
• W2046028648 modified "2023-09-25" @default.
• W2046028648 title "Design and Synthesis of Potent Bradykinin Agonists Containing a Benzothiazepine Moiety" @default.
• W2046028648 cites W1505408758 @default.
• W2046028648 cites W192443206 @default.
• W2046028648 cites W1967881203 @default.
• W2046028648 cites W1988725357 @default.
• W2046028648 cites W1990332976 @default.
• W2046028648 cites W1995793238 @default.
• W2046028648 cites W2007826751 @default.
• W2046028648 cites W2020385538 @default.
• W2046028648 cites W2038655785 @default.
• W2046028648 cites W2041911955 @default.
• W2046028648 cites W2057607923 @default.
• W2046028648 cites W2059756213 @default.
• W2046028648 cites W2067349865 @default.
• W2046028648 cites W2068989585 @default.
• W2046028648 cites W2090116806 @default.
• W2046028648 cites W2091588586 @default.
• W2046028648 cites W2103006293 @default.
• W2046028648 cites W2137926707 @default.
• W2046028648 cites W4240360688 @default.
• W2046028648 doi "https://doi.org/10.1021/jm9901529" @default.
• W2046028648 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10514288" @default.
• W2046028648 hasPublicationYear "1999" @default.
• W2046028648 type Work @default.
• W2046028648 sameAs 2046028648 @default.
• W2046028648 citedByCount "51" @default.
• W2046028648 countsByYear W20460286482012 @default.
• W2046028648 countsByYear W20460286482013 @default.
• W2046028648 countsByYear W20460286482014 @default.
• W2046028648 countsByYear W20460286482015 @default.
• W2046028648 countsByYear W20460286482016 @default.
• W2046028648 countsByYear W20460286482017 @default.
• W2046028648 countsByYear W20460286482018 @default.
• W2046028648 countsByYear W20460286482020 @default.
• W2046028648 countsByYear W20460286482021 @default.
• W2046028648 countsByYear W20460286482022 @default.
• W2046028648 crossrefType "journal-article" @default.
• W2046028648 hasAuthorship W2046028648A5010082819 @default.
• W2046028648 hasAuthorship W2046028648A5030232036 @default.
• W2046028648 hasAuthorship W2046028648A5045844512 @default.
• W2046028648 hasAuthorship W2046028648A5045906192 @default.
• W2046028648 hasAuthorship W2046028648A5052978566 @default.
• W2046028648 hasAuthorship W2046028648A5059138865 @default.
• W2046028648 hasAuthorship W2046028648A5061913955 @default.
• W2046028648 hasAuthorship W2046028648A5068275277 @default.
• W2046028648 hasAuthorship W2046028648A5072843336 @default.
• W2046028648 hasAuthorship W2046028648A5080510828 @default.
• W2046028648 hasConcept C153939273 @default.
• W2046028648 hasConcept C170493617 @default.
• W2046028648 hasConcept C185592680 @default.
• W2046028648 hasConcept C202751555 @default.
• W2046028648 hasConcept C2776568683 @default.
• W2046028648 hasConcept C2776885963 @default.
• W2046028648 hasConcept C2777411675 @default.
• W2046028648 hasConcept C2778122271 @default.
• W2046028648 hasConcept C2779138802 @default.
• W2046028648 hasConcept C2779591629 @default.
• W2046028648 hasConcept C515207424 @default.
• W2046028648 hasConcept C55493867 @default.
• W2046028648 hasConcept C71240020 @default.
• W2046028648 hasConceptScore W2046028648C153939273 @default.
• W2046028648 hasConceptScore W2046028648C170493617 @default.
• W2046028648 hasConceptScore W2046028648C185592680 @default.
• W2046028648 hasConceptScore W2046028648C202751555 @default.
• W2046028648 hasConceptScore W2046028648C2776568683 @default.
• W2046028648 hasConceptScore W2046028648C2776885963 @default.
• W2046028648 hasConceptScore W2046028648C2777411675 @default.
• W2046028648 hasConceptScore W2046028648C2778122271 @default.
• W2046028648 hasConceptScore W2046028648C2779138802 @default.
• W2046028648 hasConceptScore W2046028648C2779591629 @default.
• W2046028648 hasConceptScore W2046028648C515207424 @default.
• W2046028648 hasConceptScore W2046028648C55493867 @default.
• W2046028648 hasConceptScore W2046028648C71240020 @default.
• W2046028648 hasIssue "20" @default.
• W2046028648 hasLocation W20460286481 @default.
• W2046028648 hasLocation W20460286482 @default.
• W2046028648 hasOpenAccess W2046028648 @default.
• W2046028648 hasPrimaryLocation W20460286481 @default.
• W2046028648 hasRelatedWork W1598385871 @default.
• W2046028648 hasRelatedWork W1972746753 @default.
• W2046028648 hasRelatedWork W2010464930 @default.
• W2046028648 hasRelatedWork W2017773884 @default.
• W2046028648 hasRelatedWork W2019722743 @default.
• W2046028648 hasRelatedWork W2053635170 @default.

• next