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- W2046030304 abstract "This study was performed to find out whether the two common modes of administration of atropine and neostigmine used for reversal of neuromuscular blockade - neostigmine preceded by atropine, or both drugs given simultaneously - differ in their effects on airway resistance.Peak expiratory flow (PEF) and airway resistance (Raw) were measured in eight healthy volunteers after intravenous administration of 1) a placebo, 2) atropine only (0.0075 mg/kg), 3) neostigmine (0.015 mg/kg) preceded by atropine and 4) atropine together with neostigmine. Airway resistance and thoracic gas volume (Vtg) were measured with a volume-constant body plethysmograph. No statistically significant differences were found when the changes in PEF, Raw and Raw x Vts from the basal values were compared between the four experiments. At 30 min Raw was decreased by 28.6% after atropine, but this decrease is not significantly different from that after placebo (21.4%).ZUSAMMENFASSUNGDiese Untersuchung wurde unternommen, um herauszufinden, ob die zwei gebrauchlichen Anwendungsarten von Atropin und Neostigmin zur Aufhebung einer neuromuskularen Blockade - Atropin vor Neostigmin oder beide Mittel gleichzeitig - in ihrer Wirkung auf den Atemwegswiderstand differieren.Bei acht gesunden Probanden wurden PEF (ex-spiratorischer Spitzenstrom) und Raw (Atemwegswiderstand) gemessen und zwar nach i.v. Verabreichung von 1) einem Plazebo, 2) Atropin allein (0,0075 mg/kg), 3) Neostigmin (0,015 mg/kg) im Anschlus an Atropin und 4) Atropin und Neostigmin gleichzeitig. Atemwegswiderstand und thorakales Gasvolumen (Vtg) wurden mittels volumenkonstantem Ganzkorper-Plethysmographen bestimmt. Beim Vergleich der Veranderungen von PEF, Raw und Raw x Vtb gegenuber den Ausgangswerten ergab sich kein signifikanter Unterschied zwischen den vier Versuchsreihen. 30 Minuten nach Atropin war Raw um 28,6% vermindert, doch unterschied sich diese Abnahme nicht signifikant von der nach dem Plazebo gefundenen (21,4%)." @default.
- W2046030304 created "2016-06-24" @default.
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- W2046030304 date "1974-09-01" @default.
- W2046030304 modified "2023-09-27" @default.
- W2046030304 title "Atropine, Neostigmine and Airway Resistance" @default.
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- W2046030304 doi "https://doi.org/10.1111/j.1399-6576.1974.tb00862.x" @default.
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