Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046030804> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2046030804 endingPage "361" @default.
- W2046030804 startingPage "361" @default.
- W2046030804 abstract "Intrathecal (IT) opioid and local anesthetic combinations are popular for labor analgesia because of rapid, effective pain relief, but the duration of analgesia is limited. This study was undertaken to determine whether the addition of clonidine and neostigmine to IT bupivacaine-fentanyl would increase the duration of analgesia without increasing side effects for patients in labor.Forty-five healthy parturients in active labor were randomized to receive a 2-ml IT dose of one of the following dextrose-containing solutions using the combined spinal-epidural technique: (1) bupivacaine 2.5 mg and fentanyl 25 microg (BF); (2) BF plus clonidine 30 microg (BFC); or (3) BFC plus neostigmine 10 microg (BFCN). Pain, sensory levels, motor block, side effects, maternal vital signs, and fetal heart rate were systematically assessed.Patients administered BFCN had significantly longer analgesia (165+/-32 min) than those who received BF (90+/-21 min; P<0.001) or BFC (123+/-21 min; P<0.001). Pain scores, block characteristics, maternal vital signs, Apgar scores, maternal satisfaction, and side effects were similar among groups except for nausea, which was significantly greater in the BFCN group (P<0.05 as compared with BFC).The addition of clonidine and neostigmine significantly increased the duration of analgesia from IT bupivacaine-fentanyl during labor, but neostigmine caused more nausea. Although serious side effects were not observed in this study, safety must be further addressed before the routine use of multiple IT drugs is advocated." @default.
- W2046030804 created "2016-06-24" @default.
- W2046030804 creator A5002523551 @default.
- W2046030804 creator A5050519898 @default.
- W2046030804 creator A5050785586 @default.
- W2046030804 creator A5074472864 @default.
- W2046030804 creator A5077133216 @default.
- W2046030804 creator A5091160541 @default.
- W2046030804 date "2000-02-01" @default.
- W2046030804 modified "2023-10-18" @default.
- W2046030804 title "Low-dose Clonidine and Neostigmine Prolong the Duration of Intrathecal Bupivacaine–Fentanyl for Labor Analgesia" @default.
- W2046030804 doi "https://doi.org/10.1097/00000542-200002000-00016" @default.
- W2046030804 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10691221" @default.
- W2046030804 hasPublicationYear "2000" @default.
- W2046030804 type Work @default.
- W2046030804 sameAs 2046030804 @default.
- W2046030804 citedByCount "80" @default.
- W2046030804 countsByYear W20460308042012 @default.
- W2046030804 countsByYear W20460308042014 @default.
- W2046030804 countsByYear W20460308042015 @default.
- W2046030804 countsByYear W20460308042016 @default.
- W2046030804 countsByYear W20460308042017 @default.
- W2046030804 countsByYear W20460308042018 @default.
- W2046030804 countsByYear W20460308042020 @default.
- W2046030804 countsByYear W20460308042021 @default.
- W2046030804 crossrefType "journal-article" @default.
- W2046030804 hasAuthorship W2046030804A5002523551 @default.
- W2046030804 hasAuthorship W2046030804A5050519898 @default.
- W2046030804 hasAuthorship W2046030804A5050785586 @default.
- W2046030804 hasAuthorship W2046030804A5074472864 @default.
- W2046030804 hasAuthorship W2046030804A5077133216 @default.
- W2046030804 hasAuthorship W2046030804A5091160541 @default.
- W2046030804 hasConcept C172680121 @default.
- W2046030804 hasConcept C2777411258 @default.
- W2046030804 hasConcept C2778052368 @default.
- W2046030804 hasConcept C2778399450 @default.
- W2046030804 hasConcept C2778994108 @default.
- W2046030804 hasConcept C2779234561 @default.
- W2046030804 hasConcept C2780580376 @default.
- W2046030804 hasConcept C2781072394 @default.
- W2046030804 hasConcept C2781328992 @default.
- W2046030804 hasConcept C2991701371 @default.
- W2046030804 hasConcept C42219234 @default.
- W2046030804 hasConcept C54355233 @default.
- W2046030804 hasConcept C71924100 @default.
- W2046030804 hasConcept C86803240 @default.
- W2046030804 hasConceptScore W2046030804C172680121 @default.
- W2046030804 hasConceptScore W2046030804C2777411258 @default.
- W2046030804 hasConceptScore W2046030804C2778052368 @default.
- W2046030804 hasConceptScore W2046030804C2778399450 @default.
- W2046030804 hasConceptScore W2046030804C2778994108 @default.
- W2046030804 hasConceptScore W2046030804C2779234561 @default.
- W2046030804 hasConceptScore W2046030804C2780580376 @default.
- W2046030804 hasConceptScore W2046030804C2781072394 @default.
- W2046030804 hasConceptScore W2046030804C2781328992 @default.
- W2046030804 hasConceptScore W2046030804C2991701371 @default.
- W2046030804 hasConceptScore W2046030804C42219234 @default.
- W2046030804 hasConceptScore W2046030804C54355233 @default.
- W2046030804 hasConceptScore W2046030804C71924100 @default.
- W2046030804 hasConceptScore W2046030804C86803240 @default.
- W2046030804 hasIssue "2" @default.
- W2046030804 hasLocation W20460308041 @default.
- W2046030804 hasLocation W20460308042 @default.
- W2046030804 hasOpenAccess W2046030804 @default.
- W2046030804 hasPrimaryLocation W20460308041 @default.
- W2046030804 hasRelatedWork W1566699393 @default.
- W2046030804 hasRelatedWork W1998833227 @default.
- W2046030804 hasRelatedWork W2033217020 @default.
- W2046030804 hasRelatedWork W2038752218 @default.
- W2046030804 hasRelatedWork W2046030804 @default.
- W2046030804 hasRelatedWork W2347544520 @default.
- W2046030804 hasRelatedWork W2403521446 @default.
- W2046030804 hasRelatedWork W3041062497 @default.
- W2046030804 hasRelatedWork W3203219368 @default.
- W2046030804 hasRelatedWork W4249630745 @default.
- W2046030804 hasVolume "92" @default.
- W2046030804 isParatext "false" @default.
- W2046030804 isRetracted "false" @default.
- W2046030804 magId "2046030804" @default.
- W2046030804 workType "article" @default.