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- W2046031269 abstract "Many allergens share several biophysical characteristics, including the capability to undergo oligomerization. The dimerization mechanism in Bet v 1 and its allergenic properties are so far poorly understood. Here, we report crystal structures of dimeric Bet v 1, revealing a noncanonical incorporation of cysteine at position 5 instead of genetically encoded tyrosine. Cysteine polysulfide bridging stabilized different dimeric assemblies, depending on the polysulfide linker length. These dimers represent quaternary arrangements that are frequently observed in related proteins, reflecting their prevalence in unmodified Bet v 1. These conclusions were corroborated by characteristic immunologic properties of monomeric and dimeric allergen variants. Hereby, residue 5 could be identified as an allergenic hot spot in Bet v 1. The presented results refine fundamental principles in protein chemistry and emphasize the importance of protein modifications in understanding the molecular basis of allergenicity." @default.
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- W2046031269 date "2014-01-01" @default.
- W2046031269 modified "2023-10-09" @default.
- W2046031269 title "Stabilization of the Dimeric Birch Pollen Allergen Bet v 1 Impacts Its Immunological Properties" @default.
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- W2046031269 doi "https://doi.org/10.1074/jbc.m113.518795" @default.
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