FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046064462> ?p ?o ?g. }

• W2046064462 endingPage "159" @default.
• W2046064462 startingPage "153" @default.
• W2046064462 abstract "The rate of dissolution of drugs remains one of the most challenging aspects in formulation development of poorly water-soluble drugs. The meloxicam, a low molecular analgetic for oral administration, exhibits a slow dissolution. To improve the dissolution rate, the drug was formulated in a nanosuspension by using an emulsion–diffusion method, high-pressure homogenization or sonication. Optimization of the technological parameters (organic solvents, stabilizers, homogenization procedure and recovery of particles) allowed the formation of nanosuspensions with a particle size of 200–900 nm. SEM imaging confirmed the nanosized drug particles. Use of an SMCR method on the XRPD patterns of the nanosuspensions revealed the crystalline form of the drug and the strong interaction between meloxicam and the stabilizer. The rate of dissolution of the dried meloxicam nanosuspension was enhanced (90% in 5 min), relative to that of raw meloxicam (15% in 5 min), mainly due to the formation of nanosized particles. These results indicate the suitability of formulation procedure for preparation of nanosized poorly water-soluble drug with significantly improved in vitro dissolution rate, and thus possibly enhance fast onset of therapeutic drug effect." @default.
• W2046064462 created "2016-06-24" @default.
• W2046064462 creator A5008295598 @default.
• W2046064462 creator A5019331721 @default.
• W2046064462 creator A5021223261 @default.
• W2046064462 creator A5032419222 @default.
• W2046064462 creator A5035921957 @default.
• W2046064462 creator A5084665031 @default.
• W2046064462 date "2009-11-01" @default.
• W2046064462 modified "2023-10-10" @default.
• W2046064462 title "Investigation of preparation parameters to improve the dissolution of poorly water-soluble meloxicam" @default.
• W2046064462 cites W1965778750 @default.
• W2046064462 cites W1968054977 @default.
• W2046064462 cites W1973312375 @default.
• W2046064462 cites W1975526804 @default.
• W2046064462 cites W2001596955 @default.
• W2046064462 cites W2005326677 @default.
• W2046064462 cites W2006185729 @default.
• W2046064462 cites W2015560755 @default.
• W2046064462 cites W2018222606 @default.
• W2046064462 cites W2022119055 @default.
• W2046064462 cites W2024349178 @default.
• W2046064462 cites W2039521277 @default.
• W2046064462 cites W2041487377 @default.
• W2046064462 cites W2048761928 @default.
• W2046064462 cites W2050677715 @default.
• W2046064462 cites W2056211275 @default.
• W2046064462 cites W2059225643 @default.
• W2046064462 cites W2066426421 @default.
• W2046064462 cites W2070651699 @default.
• W2046064462 cites W2083642073 @default.
• W2046064462 cites W2122480711 @default.
• W2046064462 cites W2122635512 @default.
• W2046064462 cites W2131288551 @default.
• W2046064462 cites W2152352703 @default.
• W2046064462 cites W2182692795 @default.
• W2046064462 cites W4233194598 @default.
• W2046064462 doi "https://doi.org/10.1016/j.ijpharm.2009.07.009" @default.
• W2046064462 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19616609" @default.
• W2046064462 hasPublicationYear "2009" @default.
• W2046064462 type Work @default.
• W2046064462 sameAs 2046064462 @default.
• W2046064462 citedByCount "80" @default.
• W2046064462 countsByYear W20460644622012 @default.
• W2046064462 countsByYear W20460644622013 @default.
• W2046064462 countsByYear W20460644622014 @default.
• W2046064462 countsByYear W20460644622015 @default.
• W2046064462 countsByYear W20460644622016 @default.
• W2046064462 countsByYear W20460644622017 @default.
• W2046064462 countsByYear W20460644622018 @default.
• W2046064462 countsByYear W20460644622019 @default.
• W2046064462 countsByYear W20460644622020 @default.
• W2046064462 countsByYear W20460644622021 @default.
• W2046064462 countsByYear W20460644622022 @default.
• W2046064462 countsByYear W20460644622023 @default.
• W2046064462 crossrefType "journal-article" @default.
• W2046064462 hasAuthorship W2046064462A5008295598 @default.
• W2046064462 hasAuthorship W2046064462A5019331721 @default.
• W2046064462 hasAuthorship W2046064462A5021223261 @default.
• W2046064462 hasAuthorship W2046064462A5032419222 @default.
• W2046064462 hasAuthorship W2046064462A5035921957 @default.
• W2046064462 hasAuthorship W2046064462A5084665031 @default.
• W2046064462 hasConcept C104628117 @default.
• W2046064462 hasConcept C105795698 @default.
• W2046064462 hasConcept C127413603 @default.
• W2046064462 hasConcept C130217890 @default.
• W2046064462 hasConcept C147789679 @default.
• W2046064462 hasConcept C155574463 @default.
• W2046064462 hasConcept C169222746 @default.
• W2046064462 hasConcept C178790620 @default.
• W2046064462 hasConcept C185592680 @default.
• W2046064462 hasConcept C187530423 @default.
• W2046064462 hasConcept C18903297 @default.
• W2046064462 hasConcept C192562407 @default.
• W2046064462 hasConcept C2778123984 @default.
• W2046064462 hasConcept C2778722038 @default.
• W2046064462 hasConcept C2779751750 @default.
• W2046064462 hasConcept C33923547 @default.
• W2046064462 hasConcept C42360764 @default.
• W2046064462 hasConcept C43617362 @default.
• W2046064462 hasConcept C71924100 @default.
• W2046064462 hasConcept C86803240 @default.
• W2046064462 hasConcept C88380143 @default.
• W2046064462 hasConcept C98274493 @default.
• W2046064462 hasConceptScore W2046064462C104628117 @default.
• W2046064462 hasConceptScore W2046064462C105795698 @default.
• W2046064462 hasConceptScore W2046064462C127413603 @default.
• W2046064462 hasConceptScore W2046064462C130217890 @default.
• W2046064462 hasConceptScore W2046064462C147789679 @default.
• W2046064462 hasConceptScore W2046064462C155574463 @default.
• W2046064462 hasConceptScore W2046064462C169222746 @default.
• W2046064462 hasConceptScore W2046064462C178790620 @default.
• W2046064462 hasConceptScore W2046064462C185592680 @default.
• W2046064462 hasConceptScore W2046064462C187530423 @default.
• W2046064462 hasConceptScore W2046064462C18903297 @default.
• W2046064462 hasConceptScore W2046064462C192562407 @default.
• W2046064462 hasConceptScore W2046064462C2778123984 @default.
• W2046064462 hasConceptScore W2046064462C2778722038 @default.

• next