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• W2046072079 abstract "The GABA-benzodiazepine neurotransmission has been implicated in various forms of plasticity such as kindling and learning. The present study examined the effects of clonazepam (CZP), a GABA-benzodiazepine agonist, on the development of behavioral sensitization to methamphetamine (MA). Rats treated with MA (1 mg/kg, S.C.) for 10 days displayed significantly enhanced motor activity when tested with MA (1 mg/kg) after a 7-8-day withdrawal, indicating the development of behavioral sensitization. Pretreatment with CZP (0.5 and 2.0 mg/kg) prior to MA administration prevented the development of the phenomenon. Rats treated with CZP alone showed no difference in the motor activity compared to those treated with saline. These results suggest that stimulation of GABA-benzodiazepine receptors plays a role in the development of behavioral sensitization." @default.
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• W2046072079 date "1997-12-01" @default.
• W2046072079 modified "2023-10-16" @default.
• W2046072079 title "Clonazepam Prevents the Development of Sensitization to Methamphetamine" @default.
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• W2046072079 doi "https://doi.org/10.1016/s0091-3057(97)00049-x" @default.
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