FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046076113> ?p ?o ?g. }

• W2046076113 endingPage "G813" @default.
• W2046076113 startingPage "G804" @default.
• W2046076113 abstract "Activation of pancreatic stellate cells (PSCs) by transforming growth factor (TGF)-β is the key step in the development of pancreatic fibrosis, a common pathological feature of chronic pancreatitis (CP). Bone morphogenetic proteins (BMPs), members of the TGF-β superfamily, have anti-fibrogenic functions, in contrast to TGF-β, in the kidney, lung, and liver. However, it is not known whether BMPs have an anti-fibrogenic role in the pancreas. The current study was designed to investigate the potential anti-fibrogenic role of BMPs in the pancreas using an in vivo CP model and an in vitro PSC model. CP was induced by repetitive intraperitoneal injections of cerulein in adult Swiss Webster mice. The control mice received saline injections. Compared with the control, cerulein injections induced a time-dependent increase in acinar injury and progression of fibrosis and a steady increase in inflammation. Cerulein injections also induced increases of the extracellular matrix (ECM) protein fibronectin and of α-smooth muscle actin (α-SMA)-positive stellate cells (PSCs). The mice receiving cerulein injections showed increased BMP2 protein levels and phosphorylated Smad1 levels up to 4 wk and then declined at 8 wk to similar levels as the control. In vitro, the isolated mouse and human PSCs were cultured and pretreated with BMP2 followed by TGF-β treatment. BMP2 pretreatment inhibited TGF-β-induced α-SMA, fibronectin, and collagen type Ia expression. Knocking down Smad1 with small-interfering RNA reversed the inhibitory effect of BMP2 on TGF-β-induced α-SMA and fibronectin expression. Thus, BMP2 opposes the fibrogenic function of TGF-β in PSCs through the Smad1 signaling pathway." @default.
• W2046076113 created "2016-06-24" @default.
• W2046076113 creator A5018445405 @default.
• W2046076113 creator A5027490283 @default.
• W2046076113 creator A5028293886 @default.
• W2046076113 creator A5047012824 @default.
• W2046076113 creator A5058992243 @default.
• W2046076113 creator A5069168085 @default.
• W2046076113 creator A5069493060 @default.
• W2046076113 creator A5075597917 @default.
• W2046076113 creator A5088411351 @default.
• W2046076113 date "2013-05-01" @default.
• W2046076113 modified "2023-09-23" @default.
• W2046076113 title "BMP2 inhibits TGF-β-induced pancreatic stellate cell activation and extracellular matrix formation" @default.
• W2046076113 cites W1978148663 @default.
• W2046076113 cites W1978722598 @default.
• W2046076113 cites W1985268528 @default.
• W2046076113 cites W1985780641 @default.
• W2046076113 cites W1988675408 @default.
• W2046076113 cites W1989732890 @default.
• W2046076113 cites W1993345123 @default.
• W2046076113 cites W1994422927 @default.
• W2046076113 cites W2017617092 @default.
• W2046076113 cites W2027550738 @default.
• W2046076113 cites W2029382695 @default.
• W2046076113 cites W2033167962 @default.
• W2046076113 cites W2044783065 @default.
• W2046076113 cites W2059307232 @default.
• W2046076113 cites W2064756027 @default.
• W2046076113 cites W2076511007 @default.
• W2046076113 cites W2086354569 @default.
• W2046076113 cites W2090709209 @default.
• W2046076113 cites W2090774381 @default.
• W2046076113 cites W2097596227 @default.
• W2046076113 cites W2100908727 @default.
• W2046076113 cites W2102506028 @default.
• W2046076113 cites W2108360660 @default.
• W2046076113 cites W2122338989 @default.
• W2046076113 cites W2125386672 @default.
• W2046076113 cites W2143677991 @default.
• W2046076113 cites W2159836397 @default.
• W2046076113 cites W2169962767 @default.
• W2046076113 cites W2239460943 @default.
• W2046076113 doi "https://doi.org/10.1152/ajpgi.00306.2012" @default.
• W2046076113 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3652003" @default.
• W2046076113 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23429583" @default.
• W2046076113 hasPublicationYear "2013" @default.
• W2046076113 type Work @default.
• W2046076113 sameAs 2046076113 @default.
• W2046076113 citedByCount "52" @default.
• W2046076113 countsByYear W20460761132013 @default.
• W2046076113 countsByYear W20460761132014 @default.
• W2046076113 countsByYear W20460761132015 @default.
• W2046076113 countsByYear W20460761132016 @default.
• W2046076113 countsByYear W20460761132017 @default.
• W2046076113 countsByYear W20460761132018 @default.
• W2046076113 countsByYear W20460761132019 @default.
• W2046076113 countsByYear W20460761132020 @default.
• W2046076113 countsByYear W20460761132021 @default.
• W2046076113 countsByYear W20460761132022 @default.
• W2046076113 countsByYear W20460761132023 @default.
• W2046076113 crossrefType "journal-article" @default.
• W2046076113 hasAuthorship W2046076113A5018445405 @default.
• W2046076113 hasAuthorship W2046076113A5027490283 @default.
• W2046076113 hasAuthorship W2046076113A5028293886 @default.
• W2046076113 hasAuthorship W2046076113A5047012824 @default.
• W2046076113 hasAuthorship W2046076113A5058992243 @default.
• W2046076113 hasAuthorship W2046076113A5069168085 @default.
• W2046076113 hasAuthorship W2046076113A5069493060 @default.
• W2046076113 hasAuthorship W2046076113A5075597917 @default.
• W2046076113 hasAuthorship W2046076113A5088411351 @default.
• W2046076113 hasBestOaLocation W20460761132 @default.
• W2046076113 hasConcept C104317684 @default.
• W2046076113 hasConcept C118131993 @default.
• W2046076113 hasConcept C125349252 @default.
• W2046076113 hasConcept C126322002 @default.
• W2046076113 hasConcept C134018914 @default.
• W2046076113 hasConcept C176891718 @default.
• W2046076113 hasConcept C185592680 @default.
• W2046076113 hasConcept C189165786 @default.
• W2046076113 hasConcept C202751555 @default.
• W2046076113 hasConcept C2778764654 @default.
• W2046076113 hasConcept C2780559512 @default.
• W2046076113 hasConcept C30352789 @default.
• W2046076113 hasConcept C31507581 @default.
• W2046076113 hasConcept C55493867 @default.
• W2046076113 hasConcept C71924100 @default.
• W2046076113 hasConcept C86492073 @default.
• W2046076113 hasConcept C86803240 @default.
• W2046076113 hasConcept C95444343 @default.
• W2046076113 hasConceptScore W2046076113C104317684 @default.
• W2046076113 hasConceptScore W2046076113C118131993 @default.
• W2046076113 hasConceptScore W2046076113C125349252 @default.
• W2046076113 hasConceptScore W2046076113C126322002 @default.
• W2046076113 hasConceptScore W2046076113C134018914 @default.
• W2046076113 hasConceptScore W2046076113C176891718 @default.
• W2046076113 hasConceptScore W2046076113C185592680 @default.
• W2046076113 hasConceptScore W2046076113C189165786 @default.

• next