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• W2046076989 abstract "Although methylene blue (MB) is the most inexpensive photosensitizer with promising applications in the photodynamic therapy (PDT) for its high quantum yield of singlet oxygen generation, the clinical use of MB has been limited by its rapid enzymatic reduction in the biological environment. To enhance PDT efficacy of MB by preventing the enzymatic reduction, we have developed a new mineralization method to produce highly biocompatible MB-loaded calcium phosphate (CaP-MB) nanoparticles in the presence of polymer templates. The resulting CaP-MB nanoparticles exhibited spherical shape with a size of under 50 nm. Fourier transform infrared (FT-IR) and zeta-potential analyses confirmed the insertion of MB into the CaP-MB nanoparticles. The encapsulation of MB in CaP nanoparticles could effectively protect MB from the enzymatic reduction. In addition, the CaP-MB nanoparticles exhibited a good biocompatibility in the dark condition and significantly enhanced PDT efficacy due to apoptotic cell death against human breast cancer cells as compared with free MB, implying that CaP-MB nanoparticle system might be potentially applicable in PDT." @default.
• W2046076989 created "2016-06-24" @default.
• W2046076989 creator A5036355328 @default.
• W2046076989 creator A5075894873 @default.
• W2046076989 date "2015-05-01" @default.
• W2046076989 modified "2023-09-25" @default.
• W2046076989 title "Enhanced photodynamic therapy efficacy of methylene blue-loaded calcium phosphate nanoparticles" @default.
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• W2046076989 doi "https://doi.org/10.1016/j.jphotobiol.2015.02.022" @default.
• W2046076989 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25794464" @default.
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