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• W2046079563 abstract "S-nitrosoglutathione (GSNO) is a physiological nitric oxide molecule which regulates biological activities of target proteins via s-nitrosylation leading to attenuation of chronic inflammation. In this study we evaluated the therapeutic efficacy of GSNO in experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis. Oral administration of GSNO (0.5 or 1.0 mg/kg) reduced disease progression in chronic models (SJL and C57BL/6) of EAE induced with PLP((139-151)) or MOG((35-55)) peptides, respectively. GSNO attenuated EAE disease by reducing the production of IL17 (from Th(i) or Th17 cells) and the infiltration of CD4 T cells into the central nervous system without affecting the levels of Th1 (IFN gamma) and Th2 (IL4) immune responses. Inhibition of IL17 was observed in T cells under normal as well as Th17 skewed conditions. In vitro studies showed that the phosphorylation of STAT3 and expression of ROR gamma, key regulators of IL17 signaling, were reduced while phosphorylation of STAT4 or STAT6 and expression of T-bet or GATA3 remained unaffected, suggesting that GSNO preferentially targets Th17 cells. Collectively, GSNO attenuated EAE via modulation of Th17 cells and its effects are independent of Th1 or Th2 cells functions, indicating that it may have therapeutic potential for Th17-mediated autoimmune diseases." @default.
• W2046079563 created "2016-06-24" @default.
• W2046079563 creator A5032747758 @default.
• W2046079563 creator A5069876449 @default.
• W2046079563 creator A5088241551 @default.
• W2046079563 date "2010-01-21" @default.
• W2046079563 modified "2023-09-26" @default.
• W2046079563 title "S-nitrosoglutathione a Physiologic Nitric Oxide Carrier Attenuates Experimental Autoimmune Encephalomyelitis" @default.
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• W2046079563 doi "https://doi.org/10.1007/s11481-009-9187-x" @default.
• W2046079563 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2965418" @default.
• W2046079563 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20091246" @default.
• W2046079563 hasPublicationYear "2010" @default.
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