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• W2046083532 abstract "EVERAL thousand metabolic diseases develop because of mutations or deletions in cellular genes, resulting in a deficiency or absence of the proteins required for cellular metabolism (1). In many of these inborn errors of metabolism the dysfunctionality of the liver is responsible for the onset and maintenance of the disease. Well-known examples are hemophilia A and B due to deficiencies of factor VIII and IX, respectively, or hypercholesterolemia and premature coronary disease due to inherited deficiencies of the low density lipoprotein (LDL) receptors that are required for the uptake of cholesterol-transporting lipoproteins. Other monogenic diseases primarily affecting liver function are Wilson’s disease, urea cycle disorders, lysosomal storage diseases and phenylketonuria. For some of these diseases, a possible method of treatment is to remove the deficient liver and to replace it with a functional organ (2). However, orthotopic liver transplantation is associated with considerable morbidity and mortality, and requires lifelong immunosuppression. An alternative mode of treatment of genetic diseases is the transfer of therapeutic nucleic acids into the affected organs. The most attractive concept would be the replacement of the defective gene by a copy of the functional gene. Unfortunately, no reliable and safe techniques allowing the site-specific integration of DNA into the human genome are available at the moment (3). Therefore, almost all methods of genetic treatment focus on simply transferring the therapeutic gene into somatic cells without replacing the abnormal gene. Gene transfer into the target organs can be per" @default.
• W2046083532 created "2016-06-24" @default.
• W2046083532 creator A5042895691 @default.
• W2046083532 creator A5055436543 @default.
• W2046083532 date "1995-12-01" @default.
• W2046083532 modified "2023-10-18" @default.
• W2046083532 title "Liver-directed gene therapy: molecular tools and current preclinical and clinical studies" @default.
• W2046083532 cites W1489436358 @default.
• W2046083532 cites W1545653070 @default.
• W2046083532 cites W1549884641 @default.
• W2046083532 cites W1552687651 @default.
• W2046083532 cites W1554429518 @default.
• W2046083532 cites W1576238436 @default.
• W2046083532 cites W1580329779 @default.
• W2046083532 cites W1647141819 @default.
• W2046083532 cites W1675652804 @default.
• W2046083532 cites W170859630 @default.
• W2046083532 cites W1820433267 @default.
• W2046083532 cites W1887819598 @default.
• W2046083532 cites W1937217752 @default.
• W2046083532 cites W1963861474 @default.
• W2046083532 cites W1965039409 @default.
• W2046083532 cites W1965351187 @default.
• W2046083532 cites W196981708 @default.
• W2046083532 cites W1973705988 @default.
• W2046083532 cites W1979541866 @default.
• W2046083532 cites W1997482819 @default.
• W2046083532 cites W1998290936 @default.
• W2046083532 cites W1999081985 @default.
• W2046083532 cites W1999369189 @default.
• W2046083532 cites W2003306608 @default.
• W2046083532 cites W2008224025 @default.
• W2046083532 cites W2013359336 @default.
• W2046083532 cites W2016138321 @default.
• W2046083532 cites W2016200465 @default.
• W2046083532 cites W2019378981 @default.
• W2046083532 cites W2019612944 @default.
• W2046083532 cites W2021340621 @default.
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• W2046083532 cites W2023184383 @default.
• W2046083532 cites W2023532191 @default.
• W2046083532 cites W2023962152 @default.
• W2046083532 cites W2024291973 @default.
• W2046083532 cites W2024863470 @default.
• W2046083532 cites W2028480209 @default.
• W2046083532 cites W2029426142 @default.
• W2046083532 cites W2036693497 @default.
• W2046083532 cites W2038036971 @default.
• W2046083532 cites W2044296969 @default.
• W2046083532 cites W2046999910 @default.
• W2046083532 cites W2052446259 @default.
• W2046083532 cites W2062422615 @default.
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• W2046083532 cites W2082032640 @default.
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• W2046083532 cites W2125667082 @default.
• W2046083532 cites W2136933525 @default.
• W2046083532 cites W2139784464 @default.
• W2046083532 cites W2148290408 @default.
• W2046083532 cites W2151142281 @default.
• W2046083532 cites W2152021578 @default.
• W2046083532 cites W2153450253 @default.
• W2046083532 cites W2156521514 @default.
• W2046083532 cites W2160327135 @default.
• W2046083532 cites W2161340273 @default.
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• W2046083532 doi "https://doi.org/10.1016/0168-8278(95)80044-1" @default.
• W2046083532 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8750177" @default.
• W2046083532 hasPublicationYear "1995" @default.
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