FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046083906> ?p ?o ?g. }

• W2046083906 endingPage "1001" @default.
• W2046083906 startingPage "990" @default.
• W2046083906 abstract "The neuronal nitric oxide synthase (nNOS) inhibitor, 7-nitroindazole (7-NI) is neuroprotective against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism. Monoamine oxidase (MAO)-B inhibitory action partially contributes to this effect. We tested the hypothesis that 7-NI could be a powerful hydroxyl radical (OH) scavenger, and interferes with oxidative stress caused by MPTP. We measured OH, reduced glutathione (GSH), as well as superoxide dismutase (SOD) and catalase activities in the nucleus caudatus putamen and substantia nigra of Balb/c mice following MPTP and/or 7-NI administration. The nNOS inhibitor caused dose-dependent inhibition in the production of OH in (i) Fenton-like reaction employing ferrous citrate in a cell-free system in test tubes, (ii) in isolated mitochondrial preparation in presence of MPP+, and (iii) in the striatum of mice systemically treated with MPTP. An MPTP-induced depletion of GSH in both the nuclei was blocked by 7-NI, which was dose-dependent (10-50mg/kg), but independent of MAO-B inhibition. The nNOS-mediated recovery of GSH paralleled attenuation of MPTP-induced depletion of striatal dopamine. MPTP-induced increase in the activities of striatal or nigral SOD and catalase were significantly attenuated by 7-NI treatment. These results suggest potent antioxidant action of 7-NI in its neuroprotective effects against MPTP-induced neurotoxicity." @default.
• W2046083906 created "2016-06-24" @default.
• W2046083906 creator A5015079783 @default.
• W2046083906 creator A5039743902 @default.
• W2046083906 creator A5074537696 @default.
• W2046083906 date "2008-05-01" @default.
• W2046083906 modified "2023-09-26" @default.
• W2046083906 title "In vitro and in vivo evidences that antioxidant action contributes to the neuroprotective effects of the neuronal nitric oxide synthase and monoamine oxidase-B inhibitor, 7-nitroindazole" @default.
• W2046083906 cites W1530199299 @default.
• W2046083906 cites W1542142828 @default.
• W2046083906 cites W1546722893 @default.
• W2046083906 cites W1569800962 @default.
• W2046083906 cites W1591253779 @default.
• W2046083906 cites W1753183749 @default.
• W2046083906 cites W1775749144 @default.
• W2046083906 cites W191793640 @default.
• W2046083906 cites W1926494419 @default.
• W2046083906 cites W1964671322 @default.
• W2046083906 cites W1966007019 @default.
• W2046083906 cites W1970974990 @default.
• W2046083906 cites W1971474539 @default.
• W2046083906 cites W1974350895 @default.
• W2046083906 cites W1975739117 @default.
• W2046083906 cites W1976229428 @default.
• W2046083906 cites W1976803511 @default.
• W2046083906 cites W1985285096 @default.
• W2046083906 cites W1985351555 @default.
• W2046083906 cites W1988535499 @default.
• W2046083906 cites W1993332769 @default.
• W2046083906 cites W1997243628 @default.
• W2046083906 cites W1999649376 @default.
• W2046083906 cites W2005089402 @default.
• W2046083906 cites W2011860530 @default.
• W2046083906 cites W2012326377 @default.
• W2046083906 cites W2013026308 @default.
• W2046083906 cites W2017480610 @default.
• W2046083906 cites W2024839964 @default.
• W2046083906 cites W2029682063 @default.
• W2046083906 cites W2033270976 @default.
• W2046083906 cites W2040831177 @default.
• W2046083906 cites W2042782418 @default.
• W2046083906 cites W2044158166 @default.
• W2046083906 cites W2046835047 @default.
• W2046083906 cites W2052829501 @default.
• W2046083906 cites W2057323378 @default.
• W2046083906 cites W2057821937 @default.
• W2046083906 cites W2058137293 @default.
• W2046083906 cites W2061708338 @default.
• W2046083906 cites W2062384458 @default.
• W2046083906 cites W2063500181 @default.
• W2046083906 cites W2071553665 @default.
• W2046083906 cites W2073557865 @default.
• W2046083906 cites W2079849987 @default.
• W2046083906 cites W2080903859 @default.
• W2046083906 cites W2086919008 @default.
• W2046083906 cites W2088866343 @default.
• W2046083906 cites W2089951943 @default.
• W2046083906 cites W2093832364 @default.
• W2046083906 cites W2095460108 @default.
• W2046083906 cites W2105970121 @default.
• W2046083906 cites W2114881821 @default.
• W2046083906 cites W2116619064 @default.
• W2046083906 cites W2117573289 @default.
• W2046083906 cites W2130753694 @default.
• W2046083906 cites W2160162470 @default.
• W2046083906 cites W4238839638 @default.
• W2046083906 cites W4247648661 @default.
• W2046083906 cites W76065783 @default.
• W2046083906 cites W2095102778 @default.
• W2046083906 doi "https://doi.org/10.1016/j.neuint.2007.10.012" @default.
• W2046083906 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18164516" @default.
• W2046083906 hasPublicationYear "2008" @default.
• W2046083906 type Work @default.
• W2046083906 sameAs 2046083906 @default.
• W2046083906 citedByCount "45" @default.
• W2046083906 countsByYear W20460839062012 @default.
• W2046083906 countsByYear W20460839062013 @default.
• W2046083906 countsByYear W20460839062014 @default.
• W2046083906 countsByYear W20460839062015 @default.
• W2046083906 countsByYear W20460839062016 @default.
• W2046083906 countsByYear W20460839062017 @default.
• W2046083906 countsByYear W20460839062020 @default.
• W2046083906 countsByYear W20460839062021 @default.
• W2046083906 countsByYear W20460839062022 @default.
• W2046083906 countsByYear W20460839062023 @default.
• W2046083906 crossrefType "journal-article" @default.
• W2046083906 hasAuthorship W2046083906A5015079783 @default.
• W2046083906 hasAuthorship W2046083906A5039743902 @default.
• W2046083906 hasAuthorship W2046083906A5074537696 @default.
• W2046083906 hasConcept C134018914 @default.
• W2046083906 hasConcept C137183658 @default.
• W2046083906 hasConcept C178790620 @default.
• W2046083906 hasConcept C181199279 @default.
• W2046083906 hasConcept C185592680 @default.
• W2046083906 hasConcept C25498285 @default.
• W2046083906 hasConcept C2775838275 @default.
• W2046083906 hasConcept C2776024655 @default.
• W2046083906 hasConcept C2776151105 @default.

• next