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- W2046089145 abstract "In an effort to estimate the frequency of warfarin-associated necrosis in hospital, a cohort of 20,556 patients who had received warfarin during hospitalization between July 1984 through June 1987 was identified retrospectively using the Medimetrik Hospital Diagnosis and Therapy Audit database. Case-finding began with two broad screening efforts (using ICD-9CM codes), followed by concurrent clinical and algorithmic evaluations and chart abstract reviews by a panel of three experts in the field. Those cases designated by one or more experts as possible or probable cases of warfarin-associated necrosis constituted the numerator; the denominator was an estimate of the number of hospitalized patients administered warfarin who remained in the hospital for at least four days. A total of six possible cases (no probable cases were identified) of warfarin-associated necrosis were found in this population, representing a frequency of 33.5 per 100,000 with a 95 per cent confidence interval of 12.3 per 100,000 to 73.06 per 100,000. To our knowledge, this is the first observational study to estimate the frequency of warfarin-associated necrosis. The estimated should be interpreted with caution, however, due to the absence of probable cases and lack of complete information on the length of warfarin therapy. It demonstrates the need for automated databases which allow identification of drug therapy both inside and outside the hospital setting." @default.
- W2046089145 created "2016-06-24" @default.
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- W2046089145 date "1993-03-01" @default.
- W2046089145 modified "2023-09-26" @default.
- W2046089145 title "Estimation of the frequency of warfarin-associated necrosis in a large in-patient record-linked database" @default.
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- W2046089145 doi "https://doi.org/10.1002/pds.2630020206" @default.
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