FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046089552> ?p ?o ?g. }

• W2046089552 endingPage "451" @default.
• W2046089552 startingPage "447" @default.
• W2046089552 abstract "In simple transposition of the great arteries (sTGA), balloon atrial septostomy is performed prior to arterial switch to improve mixing of systemic and pulmonary circulations. Following septostomy, some patients are also given prostaglandin E2 (PGE2) until surgical repair. The aims of our study were to identify how often PGE2 is given after septostomy, the indications for starting PGE2, and the effect this has on postoperative outcome. The study was a retrospective review of infants born with sTGA between 2000 and 2005, who underwent arterial switch at Yorkhill Children’s Hospital, Glasgow. Over a 5-year period, 26 infants (16 male) with sTGA underwent septostomy. There was a significant rise in mean oxygen saturation following septostomy (mean, 61.4 ± 11.5% before, 81.5 ± 9.4% after; p < 0.05). Four of 26 (15%) did not receive PGE2 at all (group 1) and 8 of 26 (30%) received PGE2 before but not after septostomy (group 2). A total of 14 of 26 infants (54%) were given PGE2 following septostomy. This comprised 11 who received PGE2 before and after septostomy (group 3) and 3 who did not receive PGE2 prior to septostomy but did after (group 4). Groups 2 and 3 were compared directly, as they both received PGE2 before septostomy. In group 3, oxygen saturations were lower when PGE2 was started compared with saturations immediately after septostomy (45 ± 23.6% vs. 80 ± 10.3%; p < 0.05). Groups 2 and 3 showed no difference in atrial gap after septostomy (9.4 ± 3 vs. 8 ± 1 mm; p > 0.05). Fifty percent of infants in group 3 underwent echocardiography prior to restarting PGE2, which revealed a patent arterial duct in all but one patient. Despite PGE2, Group 3 had lower saturations at arterial switch compared with Group 2 (71 ± 14% vs. 82 ± 8%; p < 0.05). No difference was observed between group 2 and group 3 with regard to length of cardiopulmonary bypass (group 2, 173 ± 101.4 min, vs. group 3, 157.9 ± 42.1 min; p > 0.05). However, the Intensive Care Unit stay was longer for patients who received PGE2 following septostomy (8.5 ± 10.3 vs. 5 ± 0.93 days; p < 0.05). Total postoperative stay was also longer for infants who received PGE2 after septostomy (26.8 ± 14.3 vs. 16.8 ± 6.3 days; p < 0.05). In conclusion, the use of pulse oximetry has led to an increase in the administration of PGE2 after septostomy. PGE2 administration was associated with a longer ICU stay. The association between administration of PGE2 and longer postoperative stay supports the approach of early surgical repair with minimal preoperative medical intervention." @default.
• W2046089552 created "2016-06-24" @default.
• W2046089552 creator A5056328033 @default.
• W2046089552 creator A5086728856 @default.
• W2046089552 date "2008-12-16" @default.
• W2046089552 modified "2023-10-16" @default.
• W2046089552 title "Prostaglandin E2 After Septostomy for Simple Transposition" @default.
• W2046089552 cites W1976738963 @default.
• W2046089552 cites W1981741093 @default.
• W2046089552 cites W1992161020 @default.
• W2046089552 cites W2000530260 @default.
• W2046089552 cites W2002465298 @default.
• W2046089552 cites W2016751970 @default.
• W2046089552 cites W2067174833 @default.
• W2046089552 cites W2074990674 @default.
• W2046089552 cites W2076810386 @default.
• W2046089552 doi "https://doi.org/10.1007/s00246-008-9357-2" @default.
• W2046089552 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19083139" @default.
• W2046089552 hasPublicationYear "2008" @default.
• W2046089552 type Work @default.
• W2046089552 sameAs 2046089552 @default.
• W2046089552 citedByCount "13" @default.
• W2046089552 countsByYear W20460895522012 @default.
• W2046089552 countsByYear W20460895522013 @default.
• W2046089552 countsByYear W20460895522014 @default.
• W2046089552 countsByYear W20460895522016 @default.
• W2046089552 countsByYear W20460895522017 @default.
• W2046089552 countsByYear W20460895522020 @default.
• W2046089552 countsByYear W20460895522022 @default.
• W2046089552 crossrefType "journal-article" @default.
• W2046089552 hasAuthorship W2046089552A5056328033 @default.
• W2046089552 hasAuthorship W2046089552A5086728856 @default.
• W2046089552 hasBestOaLocation W20460895521 @default.
• W2046089552 hasConcept C141071460 @default.
• W2046089552 hasConcept C164705383 @default.
• W2046089552 hasConcept C2776064143 @default.
• W2046089552 hasConcept C2780074459 @default.
• W2046089552 hasConcept C42219234 @default.
• W2046089552 hasConcept C71924100 @default.
• W2046089552 hasConceptScore W2046089552C141071460 @default.
• W2046089552 hasConceptScore W2046089552C164705383 @default.
• W2046089552 hasConceptScore W2046089552C2776064143 @default.
• W2046089552 hasConceptScore W2046089552C2780074459 @default.
• W2046089552 hasConceptScore W2046089552C42219234 @default.
• W2046089552 hasConceptScore W2046089552C71924100 @default.
• W2046089552 hasIssue "4" @default.
• W2046089552 hasLocation W20460895521 @default.
• W2046089552 hasLocation W20460895522 @default.
• W2046089552 hasOpenAccess W2046089552 @default.
• W2046089552 hasPrimaryLocation W20460895521 @default.
• W2046089552 hasRelatedWork W1506200166 @default.
• W2046089552 hasRelatedWork W1995515455 @default.
• W2046089552 hasRelatedWork W2048182022 @default.
• W2046089552 hasRelatedWork W2080531066 @default.
• W2046089552 hasRelatedWork W2604872355 @default.
• W2046089552 hasRelatedWork W2748952813 @default.
• W2046089552 hasRelatedWork W2899084033 @default.
• W2046089552 hasRelatedWork W3031052312 @default.
• W2046089552 hasRelatedWork W3032375762 @default.
• W2046089552 hasRelatedWork W3108674512 @default.
• W2046089552 hasVolume "30" @default.
• W2046089552 isParatext "false" @default.
• W2046089552 isRetracted "false" @default.
• W2046089552 magId "2046089552" @default.
• W2046089552 workType "article" @default.