Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046090937> ?p ?o ?g. }
- W2046090937 endingPage "479" @default.
- W2046090937 startingPage "471" @default.
- W2046090937 abstract "The occurrence of systematic diurnal variations in pain thresholds has been demonstrated in human. Salivary melatonin levels change following acute pain when other factors that could explain the change have been removed or controlled. Melatonin-induced analgesia is blocked by naloxone or pinealectomy. By using selective radioligands [3H]-DAMGO, [3H]-DPDPE, [3-U69593, and 3H]-nociceptin, we have shown that the bovine pinealocytes contain delta and mu, but not kappa or ORL1 opioid receptor subtypes. In the present study, by using melatonin receptor agonists (6-chloromelatonin or 2-iodo-N-butanoyl-5-methoxytryptamine) or melatonin receptor antagonist (2-phenylmelatonin), we have shown that these agents do not compete with opioid receptor subtypes. However, we observed a time-dependent release of beta-endorphin an endogenous opioid peptide, by melatonin from mouse pituitary cells in culture. Hence, it is suggested that melatonin exerts its analgesic actions not by binding to opioid receptor subtypes but by binding to its own receptors and increasing the release of beta-endorphin." @default.
- W2046090937 created "2016-06-24" @default.
- W2046090937 creator A5000823655 @default.
- W2046090937 creator A5006523266 @default.
- W2046090937 creator A5007225617 @default.
- W2046090937 creator A5018659471 @default.
- W2046090937 creator A5025346933 @default.
- W2046090937 creator A5079552153 @default.
- W2046090937 creator A5085226245 @default.
- W2046090937 date "2005-01-01" @default.
- W2046090937 modified "2023-10-12" @default.
- W2046090937 title "Melatonin exerts its analgesic actions not by binding to opioid receptor subtypes but by increasing the release of β-endorphin an endogenous opioid" @default.
- W2046090937 cites W1775749144 @default.
- W2046090937 cites W1964093597 @default.
- W2046090937 cites W1964355636 @default.
- W2046090937 cites W1965948569 @default.
- W2046090937 cites W1967623207 @default.
- W2046090937 cites W1967690317 @default.
- W2046090937 cites W1968773017 @default.
- W2046090937 cites W1976972125 @default.
- W2046090937 cites W1981517308 @default.
- W2046090937 cites W1984641010 @default.
- W2046090937 cites W1993643724 @default.
- W2046090937 cites W2001195510 @default.
- W2046090937 cites W2016726002 @default.
- W2046090937 cites W2024556642 @default.
- W2046090937 cites W2026355319 @default.
- W2046090937 cites W2027344594 @default.
- W2046090937 cites W2028582627 @default.
- W2046090937 cites W2030735373 @default.
- W2046090937 cites W2036396565 @default.
- W2046090937 cites W2040279745 @default.
- W2046090937 cites W2040728167 @default.
- W2046090937 cites W2041935994 @default.
- W2046090937 cites W2043813981 @default.
- W2046090937 cites W2049977421 @default.
- W2046090937 cites W2053308771 @default.
- W2046090937 cites W2055873275 @default.
- W2046090937 cites W2056130856 @default.
- W2046090937 cites W2057664472 @default.
- W2046090937 cites W2060627150 @default.
- W2046090937 cites W2061602980 @default.
- W2046090937 cites W2063977634 @default.
- W2046090937 cites W2065547922 @default.
- W2046090937 cites W2073086737 @default.
- W2046090937 cites W2074631079 @default.
- W2046090937 cites W2154943301 @default.
- W2046090937 cites W2158067363 @default.
- W2046090937 cites W2336164231 @default.
- W2046090937 cites W4293247451 @default.
- W2046090937 cites W4300493309 @default.
- W2046090937 doi "https://doi.org/10.1016/j.brainresbull.2004.09.008" @default.
- W2046090937 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15639542" @default.
- W2046090937 hasPublicationYear "2005" @default.
- W2046090937 type Work @default.
- W2046090937 sameAs 2046090937 @default.
- W2046090937 citedByCount "98" @default.
- W2046090937 countsByYear W20460909372012 @default.
- W2046090937 countsByYear W20460909372013 @default.
- W2046090937 countsByYear W20460909372014 @default.
- W2046090937 countsByYear W20460909372015 @default.
- W2046090937 countsByYear W20460909372016 @default.
- W2046090937 countsByYear W20460909372017 @default.
- W2046090937 countsByYear W20460909372018 @default.
- W2046090937 countsByYear W20460909372019 @default.
- W2046090937 countsByYear W20460909372020 @default.
- W2046090937 countsByYear W20460909372021 @default.
- W2046090937 countsByYear W20460909372022 @default.
- W2046090937 countsByYear W20460909372023 @default.
- W2046090937 crossrefType "journal-article" @default.
- W2046090937 hasAuthorship W2046090937A5000823655 @default.
- W2046090937 hasAuthorship W2046090937A5006523266 @default.
- W2046090937 hasAuthorship W2046090937A5007225617 @default.
- W2046090937 hasAuthorship W2046090937A5018659471 @default.
- W2046090937 hasAuthorship W2046090937A5025346933 @default.
- W2046090937 hasAuthorship W2046090937A5079552153 @default.
- W2046090937 hasAuthorship W2046090937A5085226245 @default.
- W2046090937 hasConcept C125439840 @default.
- W2046090937 hasConcept C126322002 @default.
- W2046090937 hasConcept C134018914 @default.
- W2046090937 hasConcept C14397066 @default.
- W2046090937 hasConcept C170493617 @default.
- W2046090937 hasConcept C185592680 @default.
- W2046090937 hasConcept C2776401185 @default.
- W2046090937 hasConcept C2777803847 @default.
- W2046090937 hasConcept C2778182776 @default.
- W2046090937 hasConcept C2778680817 @default.
- W2046090937 hasConcept C2778750930 @default.
- W2046090937 hasConcept C2779886867 @default.
- W2046090937 hasConcept C2781063702 @default.
- W2046090937 hasConcept C2781269140 @default.
- W2046090937 hasConcept C3017995582 @default.
- W2046090937 hasConcept C71924100 @default.
- W2046090937 hasConcept C86803240 @default.
- W2046090937 hasConcept C88016717 @default.
- W2046090937 hasConcept C98274493 @default.
- W2046090937 hasConceptScore W2046090937C125439840 @default.
- W2046090937 hasConceptScore W2046090937C126322002 @default.