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- W2046095679 abstract "Ninety-two women with advanced breast cancer were allocated at random to receive either cytotoxic or endocrine treatment. Out of 45 women included in the cytotoxic treatment group, 22 (49%) achieved complete or partial remission of their disease, whereas of the 47 included in the endocrine treatment group, only 10 (21%) achieved such remission. Significantly longer survival times in the cytotoxic treatment group were most apparent among premenopausal women, 75% of such patients responding to cytotoxic drugs (median survival 46 weeks) compared with only 11% benefiting from ovarian ablation (median survival 12 weeks). In postmenopausal women with predominantly soft-tissue disease, however, additive hormonal treatment with tamoxifen produced remission rates and survival times equivalent to those produced by cytotoxic drugs." @default.
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- W2046095679 date "1977-05-14" @default.
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- W2046095679 title "Comparative trial of endocrine versus cytotoxic treatment in advanced breast cancer." @default.
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- W2046095679 doi "https://doi.org/10.1136/bmj.1.6071.1248" @default.
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