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- W2046098352 abstract "Tacrine (tetrahydroaminoacridine, THA) was first available in Australia in the mid 1940s when it was used with morphine to lessen respiratory depression without affecting analgesia.<sup>1</sup>Its anticholinesterase activity eventually led to clinical trials in patients with presumptive Alzheimer's disease (AD), but these pilot studies demonstrated only modest efficacy using tacrine alone<sup>2</sup>or in combination with lecithin.<sup>3</sup>Consistent findings of a cholinergic deficit in AD make such cholinergic manipulation a theoretically attractive palliative treatment. Trials of other cholinomimetics, however, had shown at best modest results and often practical limitations—eg, choline causes a fishy skin odor and the 30-minute half-life of physostigmine is too brief for lasting clinical effects. See also p 2523. Scientific and public interest, as well as controversy, exploded in 1986 when Summers and colleagues<sup>4</sup>reported dramatic results from a double-blind, placebo-controlled trial of tacrine in 17 patients with apparent clinical diagnoses of AD. One" @default.
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- W2046098352 date "1992-11-11" @default.
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- W2046098352 title "Tacrine for Treating Alzheimer's Disease" @default.
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- W2046098352 doi "https://doi.org/10.1001/jama.1992.03490180096034" @default.
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