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- W2046110984 abstract "We report the successful use of whole yeast artificial chromosomes (YACs) as probes for direct positional cloning of novel expressed sequences in a given genomic fragment. The class I region of the human major histocompatibility complex, in particular the chromosomal fragment spanning the HLA-E locus, was investigated. The screening of a cDNA library with a 210-kb-long YAC clone led to the identification of a new gene, positionally conserved in the major histocompatibility complex of the mouse genome and encoding a putative GTP binding protein. Although its precise function remains unknown, the interspecies conservation of both sequence and map position suggests a regulatory or functional link with the histocompatibility cluster." @default.
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- W2046110984 date "1992-12-01" @default.
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- W2046110984 title "YAC-assisted cloning of a putative G-protein mapping to the MHC class I region" @default.
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- W2046110984 doi "https://doi.org/10.1016/s0888-7543(05)80105-3" @default.
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