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- W2046111181 abstract "A growing body of evidence suggests that anthocyanins and anthocyanidins may possess analgesic properties in addition to neuroprotective and anti-inflammatory activities. These functionalities suggest a role for the cannabinoid receptor (CB) in mediating biological effects. Competitive radioligand binding assays identified cyanidin (Ki = 16.2 μM) and delphinidin (Ki = 21.3 μM) as ligands with moderate affinity to human CB1. For CB2, similar affinities were achieved by cyanidin (Ki = 33.5 μM), delphinidin (Ki = 34.3 μM), and peonidin (Ki = 46.4 μM). Inhibition constants >50 μM were obtained for pelargonidin, malvidin, cyanidin-3,5-di-O-glucoside, cyanidin-3-O-glucoside, cyanidin-3-O-galactoside, and cyanidin-3-O-rutinoside for both CB subtypes." @default.
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- W2046111181 date "2009-12-01" @default.
- W2046111181 modified "2023-10-03" @default.
- W2046111181 title "An Examination of Anthocyanins' and Anthocyanidins' Affinity for Cannabinoid Receptors" @default.
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- W2046111181 doi "https://doi.org/10.1089/jmf.2008.0243" @default.
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