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• W2046116280 endingPage "175" @default.
• W2046116280 startingPage "165" @default.
• W2046116280 abstract "Modern technologies have provided the opportunity to monitor mutations in people in vivo. The subjects of this study were accidentally exposed to 137Cesium in a radiological accident that occurred in September 1987 in Goiânia, Brazil, during which more than 150 people received doses greater than 0.1 Gy and as high as 7 Gy. The objective of this study was to determine how long the hprt mutant T-cells in the peripheral blood contribute to mutant frequency by examining the time-course of the T-lymphocyte response to ionizing radiation. This report describes the results obtained over a period of 2.3 to 4.5 years subsequent to the accident, from 11 subjects with doses ranging from 1 to 7 Gy, and from nine control subjects selected from the same population. The mean In MF (+/- SE) of the control group was 2.5 (+/- 0.2) + In10(-6). The exposed group had a significantly increased mutant frequency; the mean In MF (+/- SE) were 3.3 (+/- 0.3) + In10(-6), 2.8 (+/- 0.2) + In10(-6), and 2.3 (+/- 0.2) + In10(-6), in the years 1990-1992 respectively. Based on the decline of mutant frequency and using Buckton's models [Buckton et al. (1967): Nature 214:470-473], we demonstrated that mutant T-cells have a short-term memory with a half-life of 2.1 years. This relatively short half-life limits the effective use of the hprt assay as the method of choice to monitor past exposure. The data also demonstrate a positive correlation with age, and an inverse correlation with plating efficiency." @default.
• W2046116280 created "2016-06-24" @default.
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• W2046116280 date "1996-01-01" @default.
• W2046116280 modified "2023-09-23" @default.
• W2046116280 title "Monitoringhprt mutant frequency over time in T-lymphocytes of people accidentally exposed to high doses of ionizing radiation" @default.
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• W2046116280 doi "https://doi.org/10.1002/(sici)1098-2280(1996)27:3<165::aid-em1>3.0.co;2-e" @default.
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