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• W2046119701 abstract "Inhalation of anthrax spores rapidly develops into a deadly bacteraemia and toxaemia. Anthrax toxins include the lethal factor (LF), a mitogen-activated protein kinase (MAPK)-kinase-specific metalloprotease, which acts in the cell cytosol and plays a major part in anthrax pathogenesis. Recently, screening methods have led to the discovery of LF inhibitors that are membrane permeable. This will pave the way for design of novel anthrax therapeutics that are capable of inhibiting the metalloprotease activity of LF in vivo." @default.
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• W2046119701 date "2004-06-01" @default.
• W2046119701 modified "2023-09-23" @default.
• W2046119701 title "Stop the killer: how to inhibit the anthrax lethal factor metalloprotease" @default.
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• W2046119701 doi "https://doi.org/10.1016/j.tibs.2004.04.011" @default.
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