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• W2046120871 endingPage "3171" @default.
• W2046120871 startingPage "3161" @default.
• W2046120871 abstract "The synthesis and characterization of ruthenium(II) complexes, [Ru(cyclam)(bqdi)] x ZnCl(4) (1 x ZnCl(4); cyclam = 1,4,8,11-tetraazacyclotetradecane, bqdi = o-benzoquinonediimine), [Ru(cyclam)(nqdi)] x (ClO(4))(2) (2 x (ClO(4))(2); nqdi = 2,3-naphthoquinonediimine), and [Ru(cyclam)(phi)] x (ClO(4))(2) (3 x (ClO(4))(2); phi = 9,10-phenanthroquinonediimine), are described. The DNA binding properties and biological activity of the Ru(II) complexes were studied by various biophysical and cytological techniques. As expected, only 3 showed significant binding with DNA. The thermodynamic profile of the binding of 3 and DNA was constructed by analyzing the experimental data of absorption titration and UV melting studies with the McGhee equation, van't Hoff's equation, and the Gibbs-Helmholtz equation. Compound 3 binds double-stranded DNA with a binding constant of 5.0 x 10(4) M(-1) at 20 degrees C, and the binding mode of the complex to DNA was proved to be intercalative. Cytotoxicity and induced type of cell death of 1-3 were also investigated. Basically, metal complexes with ligands of molecular shape closely related to the structure of DNA are more likely to bind DNA and possess higher toxicity." @default.
• W2046120871 created "2016-06-24" @default.
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• W2046120871 date "2002-05-17" @default.
• W2046120871 modified "2023-10-16" @default.
• W2046120871 title "Syntheses of Ruthenium(II) Quinonediimine Complexes of Cyclam and Characterization of Their DNA-Binding Activities and Cytotoxicity" @default.
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• W2046120871 doi "https://doi.org/10.1021/ic0112802" @default.
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