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• W2046121445 endingPage "486" @default.
• W2046121445 startingPage "461" @default.
• W2046121445 abstract "A theory concerning the chemical and biochemical mechanisms of thalidomide teratogenesis is presented. A considerable body of evidence suggests that the glutarimide ring of thalidomide may exert its biological activity because of its resemblance to the imide pyrimidines thymine and uracil. In addition to the glutarimide ring, thalidomide contains a moderately reactive phthalimide moiety, which allows the spontaneous formation of various glutarimide derivatives in fetal tissues. A model is proposed in which the phthalimide group reacts with small nucleophiles, most likely the polyamines, to produce a derivative(s) having a similar biochemical potential to that of cycloheximide, a glutarimide which is a powerful inhibitor of the elongation phase of protein synthesis. Interference in the elongation phase results in the selective inhibition of the translation of messages which have a high translational efficiency. Evidence is reviewed concerning the differential inhibition of protein synthesis by cycloheximide and the effects of this inhibition on various biochemical and biological processes which are critical during development and differentiation. A similar biochemical activity by the putative thalidomide derivative(s) could explain its extreme teratogenic potential. A number of parallels between the biological effects of thalidomide and cycloheximide are discussed which support the idea that a similar biochemical activity is involved. The theory readily explains many of the observed biological effects of thalidomide including the large difference between fetal and adult toxicity. In addition, evidence is reviewed which suggests that the teratogenic properties of a number of drugs which are structurally related to thalidomide may have a common chemical basis due to the similarity of their imide core structures to thymine and uracil." @default.
• W2046121445 created "2016-06-24" @default.
• W2046121445 creator A5010967815 @default.
• W2046121445 date "1984-10-01" @default.
• W2046121445 modified "2023-10-16" @default.
• W2046121445 title "Differential inhibition of protein synthesis: A possible biochemical mechanism of thalidomide teratogenesis" @default.
• W2046121445 cites W102058930 @default.
• W2046121445 cites W1415228902 @default.
• W2046121445 cites W1482528362 @default.
• W2046121445 cites W1483906344 @default.
• W2046121445 cites W1488788730 @default.
• W2046121445 cites W1491060698 @default.
• W2046121445 cites W1504539812 @default.
• W2046121445 cites W1516397282 @default.
• W2046121445 cites W1529401899 @default.
• W2046121445 cites W1532357311 @default.
• W2046121445 cites W1533334446 @default.
• W2046121445 cites W1534511042 @default.
• W2046121445 cites W1534976838 @default.
• W2046121445 cites W1540491873 @default.
• W2046121445 cites W154508226 @default.
• W2046121445 cites W1546981807 @default.
• W2046121445 cites W1559604507 @default.
• W2046121445 cites W1572011914 @default.
• W2046121445 cites W1572436872 @default.
• W2046121445 cites W1593885725 @default.
• W2046121445 cites W1600804495 @default.
• W2046121445 cites W1608389377 @default.
• W2046121445 cites W1678414597 @default.
• W2046121445 cites W1698394655 @default.
• W2046121445 cites W1840025423 @default.
• W2046121445 cites W1955063934 @default.
• W2046121445 cites W1964686931 @default.
• W2046121445 cites W1969308874 @default.
• W2046121445 cites W1970019497 @default.
• W2046121445 cites W1972608295 @default.
• W2046121445 cites W1977267751 @default.
• W2046121445 cites W1978432676 @default.
• W2046121445 cites W1986713974 @default.
• W2046121445 cites W1989360653 @default.
• W2046121445 cites W1991283020 @default.
• W2046121445 cites W1992639724 @default.
• W2046121445 cites W1993342200 @default.
• W2046121445 cites W1995022945 @default.
• W2046121445 cites W1996549624 @default.
• W2046121445 cites W1996560703 @default.
• W2046121445 cites W1998945023 @default.
• W2046121445 cites W1999157741 @default.
• W2046121445 cites W2000870753 @default.
• W2046121445 cites W2000881984 @default.
• W2046121445 cites W2001114755 @default.
• W2046121445 cites W2002610594 @default.
• W2046121445 cites W2005180809 @default.
• W2046121445 cites W2006414630 @default.
• W2046121445 cites W2008557567 @default.
• W2046121445 cites W2009641921 @default.
• W2046121445 cites W2009924204 @default.
• W2046121445 cites W2012635945 @default.
• W2046121445 cites W2014297915 @default.
• W2046121445 cites W2017300813 @default.
• W2046121445 cites W2018171442 @default.
• W2046121445 cites W2018560171 @default.
• W2046121445 cites W2020175571 @default.
• W2046121445 cites W2023948432 @default.
• W2046121445 cites W2024274215 @default.
• W2046121445 cites W2025319642 @default.
• W2046121445 cites W2025427330 @default.
• W2046121445 cites W2029141307 @default.
• W2046121445 cites W2032413267 @default.
• W2046121445 cites W2035485845 @default.
• W2046121445 cites W2036347198 @default.
• W2046121445 cites W2036353732 @default.
• W2046121445 cites W2037355625 @default.
• W2046121445 cites W2040811795 @default.
• W2046121445 cites W2042513204 @default.
• W2046121445 cites W2043985253 @default.
• W2046121445 cites W2046520058 @default.
• W2046121445 cites W2046951024 @default.
• W2046121445 cites W2047693055 @default.
• W2046121445 cites W2052182155 @default.
• W2046121445 cites W2052714085 @default.
• W2046121445 cites W2057200757 @default.
• W2046121445 cites W2063797024 @default.
• W2046121445 cites W2064598398 @default.
• W2046121445 cites W2069981797 @default.
• W2046121445 cites W2072884940 @default.
• W2046121445 cites W2073687830 @default.
• W2046121445 cites W2073728040 @default.
• W2046121445 cites W2074413700 @default.
• W2046121445 cites W2074665834 @default.
• W2046121445 cites W2076689836 @default.
• W2046121445 cites W2077678162 @default.
• W2046121445 cites W2083532061 @default.
• W2046121445 cites W2084859584 @default.
• W2046121445 cites W2086461938 @default.
• W2046121445 cites W2089802086 @default.
• W2046121445 cites W2090827556 @default.
• W2046121445 cites W2096152825 @default.

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