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• W2046127908 abstract "1. Pigeons were trained to discriminate chlordiazepoxide (CDP) from saline using two-key food reinforced drug discrimination procedures. Discriminative control by CDP was maintained despite extended training with vehicle-like doses of CDP, by using a modified fading procedure that provided for a mixture of drug discrimination training sessions preceded by an i.m. injection of either 8.0 mg/kg CDP, or a lower training dose of CDP (4.0, 2.8, 2.0, 1.4, 1.0, 0.7, or 0.5 mg/kg CDP), or saline. The lower training dose was decreased across blocks of sessions. 2. Four lower training doses (1.4, 1.0, 0.7, and 0.5 mg/kg CDP) were retrained, with 10 min of 98 dB of noise administered 75 min prior to each drug discrimination training session. Presession exposure to noise increased percent CDP-appropriate choices for each of the four lower training doses by 15-20% over those obtained previously. 3. It is concluded that brief presession exposure to loud noise increases sensitivity to the discriminative stimulus effects of low training doses of CDP." @default.
• W2046127908 created "2016-06-24" @default.
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• W2046127908 date "1997-10-01" @default.
• W2046127908 modified "2023-09-30" @default.
• W2046127908 title "Presession noise increases sensitivity to chlordiazepoxide's discriminative stimulus in pigeons" @default.
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• W2046127908 doi "https://doi.org/10.1016/s0278-5846(97)00107-3" @default.
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