Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046128404> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2046128404 endingPage "57" @default.
- W2046128404 startingPage "51" @default.
- W2046128404 abstract "Background: Extensive research has been conducted regarding the mechanism of action of glyceryl trinitrate (GTN). It is currently believed that GTN undergoes a thiol-dependent metabolic pathway and releases its active metabolite, nitric oxide (NO) and/or S-nitrosothiols (R-SNO). This activates guanylyl cyclase (GC) leading to the formation of cGMP, which is responsible for the relaxation of vascular smooth muscles and the inhibition of platelet aggregation. The lack of knowledge as to the precise mechanism of GTN action and the modulation of its formation has limited the prevention of tolerance to GTN. Results: With cultured human vascular endothelial cells (EC), we showed that nitrite was first formed in endothelial cells whose concentration was dependent on reduced thiols. Cells preexposed to GTN significantly decreased the production of nitrite compared with cells that were not preexposed. Furthermore, we showed that thiols in cultured cells were oxidized during interaction with GTN, which correlated with the time of exposure to GTN. Conclusion: Nitrite is the first active intermediate of GTN metabolism in endothelial cells. The analysis of the changes of the blood nitrite and reduced thiols concentration is helpful for evaluating the vasodilatation activity of GTN during therapeutic treatments." @default.
- W2046128404 created "2016-06-24" @default.
- W2046128404 creator A5059625930 @default.
- W2046128404 creator A5063623918 @default.
- W2046128404 creator A5076923012 @default.
- W2046128404 creator A5079253575 @default.
- W2046128404 date "2001-11-01" @default.
- W2046128404 modified "2023-09-27" @default.
- W2046128404 title "A hypothesis on the metabolism of glyceryl trinitrate in vascular endothelial cells" @default.
- W2046128404 cites W1763016362 @default.
- W2046128404 cites W1773228510 @default.
- W2046128404 cites W1980930366 @default.
- W2046128404 cites W2009267091 @default.
- W2046128404 cites W2013851960 @default.
- W2046128404 cites W2059133012 @default.
- W2046128404 cites W2061432686 @default.
- W2046128404 cites W2413038000 @default.
- W2046128404 cites W1940654398 @default.
- W2046128404 cites W2503953775 @default.
- W2046128404 doi "https://doi.org/10.1016/s0009-8981(01)00649-0" @default.
- W2046128404 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11694239" @default.
- W2046128404 hasPublicationYear "2001" @default.
- W2046128404 type Work @default.
- W2046128404 sameAs 2046128404 @default.
- W2046128404 citedByCount "5" @default.
- W2046128404 countsByYear W20461284042012 @default.
- W2046128404 crossrefType "journal-article" @default.
- W2046128404 hasAuthorship W2046128404A5059625930 @default.
- W2046128404 hasAuthorship W2046128404A5063623918 @default.
- W2046128404 hasAuthorship W2046128404A5076923012 @default.
- W2046128404 hasAuthorship W2046128404A5079253575 @default.
- W2046128404 hasConcept C120770815 @default.
- W2046128404 hasConcept C123012128 @default.
- W2046128404 hasConcept C126322002 @default.
- W2046128404 hasConcept C173803235 @default.
- W2046128404 hasConcept C178790620 @default.
- W2046128404 hasConcept C185592680 @default.
- W2046128404 hasConcept C202751555 @default.
- W2046128404 hasConcept C2776120743 @default.
- W2046128404 hasConcept C2776179834 @default.
- W2046128404 hasConcept C2776384668 @default.
- W2046128404 hasConcept C2777477808 @default.
- W2046128404 hasConcept C2778827303 @default.
- W2046128404 hasConcept C2779395532 @default.
- W2046128404 hasConcept C2781324293 @default.
- W2046128404 hasConcept C2992686903 @default.
- W2046128404 hasConcept C519581460 @default.
- W2046128404 hasConcept C55493867 @default.
- W2046128404 hasConcept C62231903 @default.
- W2046128404 hasConcept C71924100 @default.
- W2046128404 hasConcept C98274493 @default.
- W2046128404 hasConceptScore W2046128404C120770815 @default.
- W2046128404 hasConceptScore W2046128404C123012128 @default.
- W2046128404 hasConceptScore W2046128404C126322002 @default.
- W2046128404 hasConceptScore W2046128404C173803235 @default.
- W2046128404 hasConceptScore W2046128404C178790620 @default.
- W2046128404 hasConceptScore W2046128404C185592680 @default.
- W2046128404 hasConceptScore W2046128404C202751555 @default.
- W2046128404 hasConceptScore W2046128404C2776120743 @default.
- W2046128404 hasConceptScore W2046128404C2776179834 @default.
- W2046128404 hasConceptScore W2046128404C2776384668 @default.
- W2046128404 hasConceptScore W2046128404C2777477808 @default.
- W2046128404 hasConceptScore W2046128404C2778827303 @default.
- W2046128404 hasConceptScore W2046128404C2779395532 @default.
- W2046128404 hasConceptScore W2046128404C2781324293 @default.
- W2046128404 hasConceptScore W2046128404C2992686903 @default.
- W2046128404 hasConceptScore W2046128404C519581460 @default.
- W2046128404 hasConceptScore W2046128404C55493867 @default.
- W2046128404 hasConceptScore W2046128404C62231903 @default.
- W2046128404 hasConceptScore W2046128404C71924100 @default.
- W2046128404 hasConceptScore W2046128404C98274493 @default.
- W2046128404 hasIssue "1-2" @default.
- W2046128404 hasLocation W20461284041 @default.
- W2046128404 hasLocation W20461284042 @default.
- W2046128404 hasOpenAccess W2046128404 @default.
- W2046128404 hasPrimaryLocation W20461284041 @default.
- W2046128404 hasRelatedWork W1986272386 @default.
- W2046128404 hasRelatedWork W2021735920 @default.
- W2046128404 hasRelatedWork W2022882793 @default.
- W2046128404 hasRelatedWork W2046128404 @default.
- W2046128404 hasRelatedWork W2050669669 @default.
- W2046128404 hasRelatedWork W2079031092 @default.
- W2046128404 hasRelatedWork W2083203405 @default.
- W2046128404 hasRelatedWork W2089968377 @default.
- W2046128404 hasRelatedWork W2160992728 @default.
- W2046128404 hasRelatedWork W2886895949 @default.
- W2046128404 hasVolume "313" @default.
- W2046128404 isParatext "false" @default.
- W2046128404 isRetracted "false" @default.
- W2046128404 magId "2046128404" @default.
- W2046128404 workType "article" @default.