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• W2046131115 abstract "Background: A new inhaled suspension formulation of mometasone furoate (MF), a potent corticosteroid with minimal systemic availability, has been developed for the treatment of asthma. This formulation is delivered by metered-dose inhaler (MDI) using the nonchlorofluorocarbon propellant hydrofluoroalkane 227 (HFA-227). Objective: The primary goal of this study was to determine the respiratory tract deposition of this formulation of MF. A secondary objective was to measure plasma concentrations of MF and a putative metabolite, 6-β-OH MF, to determine the systemic exposure to corticosteroid. Methods: This was a single-dose, open-label study in which 200 μg of technetium 99m (99mTc)-radiolabeled MF was administered to patients with asthma. Gamma scintigraphy was used to quantify lung, oropharyngeal, stomach, and MDI mouthpiece deposition patterns of MF. Results: Eleven patients, aged 21 to 47 years, with a history of asthma were enrolled in and completed the study. The mean (± SD) whole lung deposition of MF was 13.9% ± 5.7% of the metered (ex-valve) dose. The central lung zone received 5.3% ± 2.8% of the dose; the intermediate zone received 4.7% ± 1.9%; and peripheral lung deposition was 4.0% ± 1.5%. The mean (± SD) ratio of periphera to central lung deposition was 0.8 ± 0.2. Oropharyngeal deposition was 79.1% ± 8.7% of the ex-valve dose, with 6.3% ± 7.8% deposited on the MDI mouthpiece and 0.7% ± 0.5% exhaled. The majority of plasma samples taken for analysis of MF and 6-β-OH MF concentrations were below the limit of quantification (50 pg/mL) in all patients after inhalation of 200 μg 99mTc-labeled MF. Conclusion: The lung deposition of MF when administered via HFA-227 MDI is comparable to the 10% to 20% lung deposition seen with other corticosteroid suspension formulations administered by MDI that have demonstrated effectiveness in the treatment of asthma." @default.
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• W2046131115 date "2000-12-01" @default.
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• W2046131115 title "Regional lung deposition of a technetium 99m-labeled formulation of mometasone furoate administered by hydrofluoroalkane 227 metered-dose inhaler" @default.
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• W2046131115 doi "https://doi.org/10.1016/s0149-2918(00)83046-5" @default.
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