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- W2046137934 abstract "A linkage has been detected between the locus for cystic fibrosis (CF) and the proα2(I) collagen gene (COL1A2) which is located in the region q21.3→q22.1 of chromosome 7. Based on the combined linkage data derived from 50 informative two-generation nuclear families collected in Canada and Denmark, the distance between <i>COL1A2 </i>and CF is estimated to be 19 centiMorgans. Close linkage has also been detected between <i>COL1A2 </i>and the DNA marker D7S15 (formerly DOCRI-917) and the serum enzyme activity marker paraoxonase <i>(PON</i>), both of which have previously been found linked to <i>CF</i>. The results of the two-point and three-point linkage analyses indicate that the most probable order of these four genetic loci is <i>COL1A2 – </i>D7S15 <i>PON – CF</i>." @default.
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- W2046137934 date "1986-01-01" @default.
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- W2046137934 title "Linkage of cystic fibrosis to the proα 2(I) collagen gene, COL1A2, on chromosome 7" @default.
- W2046137934 doi "https://doi.org/10.1159/000132235" @default.
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