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• W2046145412 endingPage "589" @default.
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• W2046145412 abstract "Whether small-bowel motility is abnormal in the irritable bowel syndrome (IBS) is a controversy at present. The aim of our study was to compare ambulatory long-term jejunal motility in 35 IBS patients with predominant diarrhea to normal values obtained in 50 healthy controls.Twenty-four-hour motility was recorded in the proximal jejunum with a portable datalogger and tube-mounted miniature pressure sensors. Fasting motility in the waking (W) and sleeping (S) state and the motor response to a standardized evening meal of 600 kcal underwent visual and computer-aided analysis.Fasting motility in patients showed migrating motor complex (MMC) cycles of normal length and composition. Uninterrupted runs of discrete clustered contractions during phase II (W) occurred in 57% of patients and 52% of controls but had a significantly longer duration in patients (33 +/- 5 versus 19 +/- 7 min; p < 0.005). During phase II (W) IBS patients had an increase in aborally propagated contractions (41 +/- 2% versus 35 +/- 2%; p < 0.01) and higher contraction amplitudes (26.3 +/- 0.8 versus 23.0 +/- 0.5 mm Hg; p < 0.01). Similar differences were obtained during postprandial motility (47 +/- 3% versus 39 +/- 3%; p < 0.01, and 25.9 +/- 0.9 versus 23.8 +/- 0.05 mm Hg; p < 0.02). In three patients (8.6%) disturbed aboral migration of phase III and irregular burst activity, manometric features of chronic idiopathic intestinal pseudo-obstruction, were identified. Whereas 57% of patients had an entirely normal 24-h manometry, 43% had at least one finding not present in any healthy control.Small-intestinal motility is frequently but not universally abnormal in diarrhea-predominant IBS. The abnormal manometric findings are heterogeneous and range from subtle quantitative changes to severe qualitative abnormalities resembling chronic idiopathic intestinal pseudo-obstruction in a small subset of patients." @default.
• W2046145412 created "2016-06-24" @default.
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• W2046145412 date "1996-01-01" @default.
• W2046145412 modified "2023-09-27" @default.
• W2046145412 title "Ambulatory 24-Hour Jejunal Motility in Diarrhea-Predominant Irritable Bowel Syndrome" @default.
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• W2046145412 doi "https://doi.org/10.3109/00365529609009131" @default.
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