FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046146220> ?p ?o ?g. }

• W2046146220 endingPage "1142" @default.
• W2046146220 startingPage "1135" @default.
• W2046146220 abstract "Annexin-A1 (ANXA1), a glucocorticoid-regulated protein, mediates several of the anti-inflammatory actions of the glucocorticoids. Previous studies demonstrated that ANXA1 is involved in pain modulation. The current study, using ANXA1 knockout mice (ANXA1-/-), is aimed at addressing the site and mechanism of the modulatory action of ANXA1 as well as possible involvement of ANXA1 in mediating the analgesic action of glucocorticoids.The acetic acid-induced writhing response was performed in ANXA1-/- and wild-type (ANXA1+/+) mice with spinal and brain levels of prostaglandin E2 (PGE2) examined in both genotypes. The effect of the ANXA1 peptomimetic Ac2-26 as well as methylprednisolone on the writhing response and on spinal cord PGE2 of ANXA1+/+ and ANXA1-/- was compared. The expression of proteins involved in PGE2 synthesis, cytosolic phospholipase A2 (cPLA2) and cyclooxygenases (COXs), in the spinal cord of ANXA1+/+ and ANXA1-/- was also compared.ANXA1-/- mice exhibited a significantly greater writhing response and increased spinal cord levels of PGE2 compared with ANXA1+/+ mice. Ac2-26 produced analgesia and reduced spinal PGE2 levels in ANXA1+/+ and ANXA1-/- mice, whereas methylprednisolone reduced the writhing response and spinal PGE2 levels in ANXA1+/+, but not in ANXA1-/- mice. The expression of cPLA2, COX-1, COX-2 and COX-3 in spinal cord tissues was upregulated in ANXA1-/-compared with ANXA1+/+.We conclude that ANXA1 protein modulates nociceptive processing at the spinal level, by reducing synthesis of PGE2 by modulating cPLA2 and/or COX activity. The analgesic activity of methylprednisolone is mediated by spinal ANXA1." @default.
• W2046146220 created "2016-06-24" @default.
• W2046146220 creator A5001267595 @default.
• W2046146220 creator A5024875563 @default.
• W2046146220 creator A5052759191 @default.
• W2046146220 date "2008-07-01" @default.
• W2046146220 modified "2023-10-14" @default.
• W2046146220 title "Increased susceptibility of annexin-A1 null mice to nociceptive pain is indicative of a spinal antinociceptive action of annexin-A1" @default.
• W2046146220 cites W1558378327 @default.
• W2046146220 cites W1558393737 @default.
• W2046146220 cites W1594205240 @default.
• W2046146220 cites W1846687944 @default.
• W2046146220 cites W1967803403 @default.
• W2046146220 cites W1968045016 @default.
• W2046146220 cites W1972699693 @default.
• W2046146220 cites W1976468624 @default.
• W2046146220 cites W1979917335 @default.
• W2046146220 cites W1983533888 @default.
• W2046146220 cites W1994544041 @default.
• W2046146220 cites W2003824193 @default.
• W2046146220 cites W2004317005 @default.
• W2046146220 cites W2006914349 @default.
• W2046146220 cites W2011058076 @default.
• W2046146220 cites W2021592029 @default.
• W2046146220 cites W2023702942 @default.
• W2046146220 cites W2024289681 @default.
• W2046146220 cites W2026825209 @default.
• W2046146220 cites W2033109378 @default.
• W2046146220 cites W2040291484 @default.
• W2046146220 cites W2051690250 @default.
• W2046146220 cites W2052709505 @default.
• W2046146220 cites W2059566065 @default.
• W2046146220 cites W2066838089 @default.
• W2046146220 cites W2070095270 @default.
• W2046146220 cites W2090451764 @default.
• W2046146220 cites W2105484064 @default.
• W2046146220 cites W2113745276 @default.
• W2046146220 cites W2121558447 @default.
• W2046146220 cites W2122348000 @default.
• W2046146220 cites W2131154808 @default.
• W2046146220 cites W2148733966 @default.
• W2046146220 cites W2151868528 @default.
• W2046146220 cites W2169986649 @default.
• W2046146220 cites W2436937082 @default.
• W2046146220 cites W27455080 @default.
• W2046146220 cites W4293247451 @default.
• W2046146220 doi "https://doi.org/10.1038/bjp.2008.166" @default.
• W2046146220 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2451045" @default.
• W2046146220 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18469846" @default.
• W2046146220 hasPublicationYear "2008" @default.
• W2046146220 type Work @default.
• W2046146220 sameAs 2046146220 @default.
• W2046146220 citedByCount "39" @default.
• W2046146220 countsByYear W20461462202012 @default.
• W2046146220 countsByYear W20461462202013 @default.
• W2046146220 countsByYear W20461462202014 @default.
• W2046146220 countsByYear W20461462202015 @default.
• W2046146220 countsByYear W20461462202016 @default.
• W2046146220 countsByYear W20461462202017 @default.
• W2046146220 countsByYear W20461462202019 @default.
• W2046146220 countsByYear W20461462202020 @default.
• W2046146220 countsByYear W20461462202021 @default.
• W2046146220 countsByYear W20461462202022 @default.
• W2046146220 countsByYear W20461462202023 @default.
• W2046146220 crossrefType "journal-article" @default.
• W2046146220 hasAuthorship W2046146220A5001267595 @default.
• W2046146220 hasAuthorship W2046146220A5024875563 @default.
• W2046146220 hasAuthorship W2046146220A5052759191 @default.
• W2046146220 hasBestOaLocation W20461462202 @default.
• W2046146220 hasConcept C126322002 @default.
• W2046146220 hasConcept C134018914 @default.
• W2046146220 hasConcept C15490471 @default.
• W2046146220 hasConcept C169760540 @default.
• W2046146220 hasConcept C170493617 @default.
• W2046146220 hasConcept C181199279 @default.
• W2046146220 hasConcept C185592680 @default.
• W2046146220 hasConcept C190283241 @default.
• W2046146220 hasConcept C2776551241 @default.
• W2046146220 hasConcept C2777956040 @default.
• W2046146220 hasConcept C2780372218 @default.
• W2046146220 hasConcept C2780775167 @default.
• W2046146220 hasConcept C55493867 @default.
• W2046146220 hasConcept C68246026 @default.
• W2046146220 hasConcept C71924100 @default.
• W2046146220 hasConcept C86803240 @default.
• W2046146220 hasConcept C88634738 @default.
• W2046146220 hasConcept C98274493 @default.
• W2046146220 hasConceptScore W2046146220C126322002 @default.
• W2046146220 hasConceptScore W2046146220C134018914 @default.
• W2046146220 hasConceptScore W2046146220C15490471 @default.
• W2046146220 hasConceptScore W2046146220C169760540 @default.
• W2046146220 hasConceptScore W2046146220C170493617 @default.
• W2046146220 hasConceptScore W2046146220C181199279 @default.
• W2046146220 hasConceptScore W2046146220C185592680 @default.
• W2046146220 hasConceptScore W2046146220C190283241 @default.
• W2046146220 hasConceptScore W2046146220C2776551241 @default.
• W2046146220 hasConceptScore W2046146220C2777956040 @default.
• W2046146220 hasConceptScore W2046146220C2780372218 @default.

• next