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- W2046147550 abstract "Unlike other vertebrates, teleosts have rod- and cone-specific phosducins (PD-R and PD-C) in the retina. To evaluate the teleost Gbetagamma-PD systems, we isolated cDNAs encoding medaka Gbeta1 and GbetaC, which selectively expressed rods and cones. Immunohistochemical studies showed that the strong reactivity of GbetaC but not PD-C was detected in cone outer segments. In rod outer segments (ROS), PD-R reactivity was stronger in light-adapted retina than in dark-adapted retina. Western blot analyses of fractions torn from the cryosections showed that the PD-R concentration was low in dark-adapted ROS. It is suggested that PD-R is translocated to ROS and effectively downregulates the phototransduction cascade in light-adapted rods." @default.
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- W2046147550 date "2007-02-26" @default.
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- W2046147550 title "Distribution and Translocation of Photoreceptor Gβγ-phosducin System in Medaka Retina‡" @default.
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- W2046147550 doi "https://doi.org/10.1562/2006-03-03-ra-834" @default.
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