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- W2046154156 abstract "The cerebrospinal fluid (CSF) concentrations of thyrotropin-releasing hormone (TRH), substance P (SP), 5-hydroxyindoleacetic acid (5-HIAA), homovanillic acid (HVA), and 3-methoxy-4-hydroxyphenyl glycol (MHPG) were measured in 15 consecutive patients with the sleep apnea syndrome (SAS) and in healthy control subjects. Second measurements were performed 6 months after surgical treatment in 10 of the patients. The mean (± SD) concentration of TRH-like immunoreactive material (TRH-LIM) (pg/ml) did not differ significantly between patients with SAS (8.1 ± 2.8) and control subjects (7.5 ± 2.2). However, postoperatively, this concentration was increased in the six clinically cured patients with SAS, from 6.9 ± 2.7 to 9.4 ± 1.6 (p < 0.03). Substance P-like immunoreactive material (SP-LIM) was higher in untreated patients with SAS than in control subjects: 19.2 ± 6.7 versus 14.4 ± 4.2 fmol/ml (p < 0.02), and the level remained high after operation in the group treated surgically. The HVA, 5-HIAA, and MHPG concentrations were similar in patients with SAS and control subjects, and no consistent changes were found postoperatively. The CSF deviations in TRH-LIM and SP-LIM concentrations in the patients may reflect a primary central nervous system defect or they may be secondary to intermittent nocturnal hypoxia, progressive hypercapnia, and/or sleep fragmentation. In this sense, both these systems may be markers of SAS-SP as a “trait” marker and TRH as an indicator of the current state." @default.
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- W2046154156 date "1992-09-01" @default.
- W2046154156 modified "2023-09-27" @default.
- W2046154156 title "Substance P, Thyrotropin-releasing Hormone, and Monoamine Metabolites in Cerebrospinal Fluid in Sleep Apnea Patients" @default.
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- W2046154156 doi "https://doi.org/10.1164/ajrccm/146.3.784" @default.
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