FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046155010> ?p ?o ?g. }

• W2046155010 endingPage "1213" @default.
• W2046155010 startingPage "1209" @default.
• W2046155010 abstract "Placental development and genomic imprinting coevolved with parental conflict over resource distribution to mammalian offspring. The imprinted genes IGF2 and IGF2R code for the growth promoter insulin-like growth factor 2 (IGF2) and its inhibitor, mannose 6-phosphate (M6P)/IGF2 receptor (IGF2R), respectively. M6P/IGF2R of birds and fish do not recognize IGF2. In monotremes, which lack imprinting, IGF2 specifically bound M6P/IGF2R via a hydrophobic CD loop. We show that the DNA coding the CD loop in monotremes functions as an exon splice enhancer (ESE) and that structural evolution of binding site loops (AB, HI, FG) improved therian IGF2 affinity. We propose that ESE evolution led to the fortuitous acquisition of IGF2 binding by M6P/IGF2R that drew IGF2R into parental conflict; subsequent imprinting may then have accelerated affinity maturation." @default.
• W2046155010 created "2016-06-24" @default.
• W2046155010 creator A5004110744 @default.
• W2046155010 creator A5007564280 @default.
• W2046155010 creator A5016293875 @default.
• W2046155010 creator A5023025738 @default.
• W2046155010 creator A5023647594 @default.
• W2046155010 creator A5033324304 @default.
• W2046155010 creator A5035572752 @default.
• W2046155010 creator A5040594896 @default.
• W2046155010 creator A5052194762 @default.
• W2046155010 creator A5052498965 @default.
• W2046155010 creator A5055505183 @default.
• W2046155010 creator A5056074050 @default.
• W2046155010 creator A5057032048 @default.
• W2046155010 creator A5057320292 @default.
• W2046155010 creator A5062405340 @default.
• W2046155010 creator A5062811221 @default.
• W2046155010 date "2012-11-30" @default.
• W2046155010 modified "2023-10-13" @default.
• W2046155010 title "An Exon Splice Enhancer Primes IGF2:IGF2R Binding Site Structure and Function Evolution" @default.
• W2046155010 cites W133843869 @default.
• W2046155010 cites W1970009324 @default.
• W2046155010 cites W1970367879 @default.
• W2046155010 cites W1973842956 @default.
• W2046155010 cites W1978538506 @default.
• W2046155010 cites W1985714764 @default.
• W2046155010 cites W1986007518 @default.
• W2046155010 cites W1993243592 @default.
• W2046155010 cites W1993315210 @default.
• W2046155010 cites W1995184255 @default.
• W2046155010 cites W1999579544 @default.
• W2046155010 cites W2004722798 @default.
• W2046155010 cites W2008807736 @default.
• W2046155010 cites W2023262488 @default.
• W2046155010 cites W2023648355 @default.
• W2046155010 cites W2028048360 @default.
• W2046155010 cites W2031141147 @default.
• W2046155010 cites W2033144162 @default.
• W2046155010 cites W2034691490 @default.
• W2046155010 cites W2035169894 @default.
• W2046155010 cites W2036371154 @default.
• W2046155010 cites W2042195196 @default.
• W2046155010 cites W2042741202 @default.
• W2046155010 cites W2044681499 @default.
• W2046155010 cites W2060408216 @default.
• W2046155010 cites W2063675850 @default.
• W2046155010 cites W2075846725 @default.
• W2046155010 cites W2079304176 @default.
• W2046155010 cites W2081808783 @default.
• W2046155010 cites W2089054940 @default.
• W2046155010 cites W2089419766 @default.
• W2046155010 cites W2093238184 @default.
• W2046155010 cites W2104749792 @default.
• W2046155010 cites W2105952005 @default.
• W2046155010 cites W2107045646 @default.
• W2046155010 cites W2107977824 @default.
• W2046155010 cites W2110120447 @default.
• W2046155010 cites W2114459720 @default.
• W2046155010 cites W2114858580 @default.
• W2046155010 cites W2115497164 @default.
• W2046155010 cites W2116185451 @default.
• W2046155010 cites W2121743800 @default.
• W2046155010 cites W2128419388 @default.
• W2046155010 cites W2132123037 @default.
• W2046155010 cites W2135338948 @default.
• W2046155010 cites W2135706321 @default.
• W2046155010 cites W2136388877 @default.
• W2046155010 cites W2136696605 @default.
• W2046155010 cites W2140870757 @default.
• W2046155010 cites W2142177694 @default.
• W2046155010 cites W2147218892 @default.
• W2046155010 cites W2151499061 @default.
• W2046155010 cites W2151950834 @default.
• W2046155010 cites W2152382649 @default.
• W2046155010 cites W2153133532 @default.
• W2046155010 cites W2155897797 @default.
• W2046155010 cites W2157567137 @default.
• W2046155010 cites W2164194877 @default.
• W2046155010 cites W2164548935 @default.
• W2046155010 cites W2168238649 @default.
• W2046155010 cites W2169509504 @default.
• W2046155010 cites W2169707043 @default.
• W2046155010 cites W2169821755 @default.
• W2046155010 cites W2170338669 @default.
• W2046155010 cites W77849655 @default.
• W2046155010 doi "https://doi.org/10.1126/science.1228633" @default.
• W2046155010 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4658703" @default.
• W2046155010 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23197533" @default.
• W2046155010 hasPublicationYear "2012" @default.
• W2046155010 type Work @default.
• W2046155010 sameAs 2046155010 @default.
• W2046155010 citedByCount "36" @default.
• W2046155010 countsByYear W20461550102013 @default.
• W2046155010 countsByYear W20461550102014 @default.
• W2046155010 countsByYear W20461550102015 @default.
• W2046155010 countsByYear W20461550102016 @default.
• W2046155010 countsByYear W20461550102017 @default.

• next