Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046157417> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2046157417 endingPage "1243" @default.
- W2046157417 startingPage "1235" @default.
- W2046157417 abstract "The importance of glutathione transferases (GST) as a major group of detoxification enzymes is well known. The human liver possesses these enzymes in high concentration and in a multiplicity of forms. We describe here a novel glutathione transferase isoenzyme isolated from liver using glutathione affinity chromatography, DEAE-sepharose and Mono-Q ion-exchange chromatography. The isoenzyme is a dimer of approximately 25 kDa with a blocked N-termini. Its kinetic and immunological properties indicate that it belongs to the alpha-class of GSTs. Its isoelectric point (8.0) is closely related to GST alpha (pI 7.8) and GST beta (pI 8.2) reported previously. More than 70% of the amino-acid sequence of this isoenzyme has been determined by automated Edman degradation procedure. The results suggest that this isoenzyme (which we term GST 8.0) may be a heterodimer of two, closely related, novel alpha-class GST subunits. Comparisons between the amino acid sequences of these two novel alpha-class subunits with those of the other alpha-class GST subunits already known indicate changes in a number of different residues localized in the electrophilic binding site. Further studies are needed to establish whether such differences are due to allelic polymorphism of the enzyme or to the existence of additional genes for alpha-class GSTs in human liver. These results are consistent with previous data which suggest that a multitude of different GSTs, especially of alpha class, are present in the human liver providing this tissue with an efficient mechanism of protection against xenobiotic and endogenous compounds." @default.
- W2046157417 created "2016-06-24" @default.
- W2046157417 creator A5000877030 @default.
- W2046157417 creator A5010127952 @default.
- W2046157417 creator A5048917582 @default.
- W2046157417 creator A5057172017 @default.
- W2046157417 creator A5059575023 @default.
- W2046157417 creator A5075406326 @default.
- W2046157417 creator A5078807035 @default.
- W2046157417 date "1998-11-01" @default.
- W2046157417 modified "2023-09-23" @default.
- W2046157417 title "Purification and characterization of a novel alpha-class glutathione transferase from human liver" @default.
- W2046157417 cites W1520899737 @default.
- W2046157417 cites W1536923222 @default.
- W2046157417 cites W1750773183 @default.
- W2046157417 cites W1902072415 @default.
- W2046157417 cites W1968416349 @default.
- W2046157417 cites W1996108199 @default.
- W2046157417 cites W2019909028 @default.
- W2046157417 cites W2040930057 @default.
- W2046157417 cites W2041915244 @default.
- W2046157417 cites W2046750894 @default.
- W2046157417 cites W2090579519 @default.
- W2046157417 cites W2090874882 @default.
- W2046157417 cites W2100837269 @default.
- W2046157417 cites W2101108802 @default.
- W2046157417 cites W2110885671 @default.
- W2046157417 cites W2154011403 @default.
- W2046157417 cites W23248100 @default.
- W2046157417 cites W2411768669 @default.
- W2046157417 doi "https://doi.org/10.1016/s1357-2725(98)00084-3" @default.
- W2046157417 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9839448" @default.
- W2046157417 hasPublicationYear "1998" @default.
- W2046157417 type Work @default.
- W2046157417 sameAs 2046157417 @default.
- W2046157417 citedByCount "2" @default.
- W2046157417 crossrefType "journal-article" @default.
- W2046157417 hasAuthorship W2046157417A5000877030 @default.
- W2046157417 hasAuthorship W2046157417A5010127952 @default.
- W2046157417 hasAuthorship W2046157417A5048917582 @default.
- W2046157417 hasAuthorship W2046157417A5057172017 @default.
- W2046157417 hasAuthorship W2046157417A5059575023 @default.
- W2046157417 hasAuthorship W2046157417A5075406326 @default.
- W2046157417 hasAuthorship W2046157417A5078807035 @default.
- W2046157417 hasConcept C104292427 @default.
- W2046157417 hasConcept C104317684 @default.
- W2046157417 hasConcept C119795356 @default.
- W2046157417 hasConcept C153911025 @default.
- W2046157417 hasConcept C167625842 @default.
- W2046157417 hasConcept C179247698 @default.
- W2046157417 hasConcept C181199279 @default.
- W2046157417 hasConcept C2776907368 @default.
- W2046157417 hasConcept C515207424 @default.
- W2046157417 hasConcept C538909803 @default.
- W2046157417 hasConcept C55493867 @default.
- W2046157417 hasConcept C86803240 @default.
- W2046157417 hasConcept C87933860 @default.
- W2046157417 hasConcept C96294017 @default.
- W2046157417 hasConceptScore W2046157417C104292427 @default.
- W2046157417 hasConceptScore W2046157417C104317684 @default.
- W2046157417 hasConceptScore W2046157417C119795356 @default.
- W2046157417 hasConceptScore W2046157417C153911025 @default.
- W2046157417 hasConceptScore W2046157417C167625842 @default.
- W2046157417 hasConceptScore W2046157417C179247698 @default.
- W2046157417 hasConceptScore W2046157417C181199279 @default.
- W2046157417 hasConceptScore W2046157417C2776907368 @default.
- W2046157417 hasConceptScore W2046157417C515207424 @default.
- W2046157417 hasConceptScore W2046157417C538909803 @default.
- W2046157417 hasConceptScore W2046157417C55493867 @default.
- W2046157417 hasConceptScore W2046157417C86803240 @default.
- W2046157417 hasConceptScore W2046157417C87933860 @default.
- W2046157417 hasConceptScore W2046157417C96294017 @default.
- W2046157417 hasIssue "11" @default.
- W2046157417 hasLocation W20461574171 @default.
- W2046157417 hasLocation W20461574172 @default.
- W2046157417 hasOpenAccess W2046157417 @default.
- W2046157417 hasPrimaryLocation W20461574171 @default.
- W2046157417 hasRelatedWork W1536678566 @default.
- W2046157417 hasRelatedWork W1967940207 @default.
- W2046157417 hasRelatedWork W1974740274 @default.
- W2046157417 hasRelatedWork W2010000726 @default.
- W2046157417 hasRelatedWork W2012170730 @default.
- W2046157417 hasRelatedWork W2027722978 @default.
- W2046157417 hasRelatedWork W2081087128 @default.
- W2046157417 hasRelatedWork W2125667499 @default.
- W2046157417 hasRelatedWork W2216858432 @default.
- W2046157417 hasRelatedWork W4229671155 @default.
- W2046157417 hasVolume "30" @default.
- W2046157417 isParatext "false" @default.
- W2046157417 isRetracted "false" @default.
- W2046157417 magId "2046157417" @default.
- W2046157417 workType "article" @default.