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- W2046158815 abstract "espanolLos bifosfonatos constituyen un grupo de farmacos inhibidores de la resorcion osea, utilizados en el tratamiento de numerosas patologias como la osteoporosis, la enfermedad de Paget, el mieloma multiple, la hipercalcemia maligna y las metastasis oseas asociadas al cancer de mama o de prostata. El principal efecto farmacologico de los bifosfonatos es la inhibicion de la resorcion osea, mediante una disminucion de la actividad de los osteoclastos, sin intervenir en la formacion y mineralizacion del hueso. Son farmacos utilizados a nivel mundial con unos claros beneficios contrastados clinicamente. Numerosas publicaciones durante los ultimos tres anos, y debido a su utilizacion masiva, consideran que la osteonecrosis de los maxilares esta asociada al tratamiento con bifosfonatos. Es importante que los pacientes sean informados del riesgo de presentarse esta complicacion, para tener la oportunidad de someterse a procedimientos dentales previos al inicio del tratamiento. Las medidas preventivas deben realizarse antes, durante y despues del tratamiento con bifosfonatos. El tratamiento quirurgico debe reservarse para aquellos pacientes que presenten sintomas. Son necesarias nuevas investigaciones que clarifiquen esta complicacion. EnglishBiphosphonates constitute a group of inhibitors of bone resoption that are used for treating many disorders such as osteoporosis, Paget?s disease, multiple myeloma, malignant hypercalcemia and bone metastases associated with breast and prostate cancer. The main pharmacological effect of biphosphonates is the inhibition of bone resorption, mediated by a decreased function of osteoclasts without interfering in bone formation and mineralization. These drugs are used worldwide, with clear and clinically proven benefits. Several publications within the last three years consider osteonecrosis of the jaw to be associated with bisphosphonate therapy as a result of their extensive use. It is important for patients to be informed of the risk of this complication, so that they have the opportunity to asses the need for dental treatment before, during, and after treatment with biphosphonates. Surgical treatment should be reserved for those patients who are symptomatic. Further investigation is needed to completely elucidate this complication." @default.
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- W2046158815 date "2007-10-01" @default.
- W2046158815 modified "2023-09-26" @default.
- W2046158815 title "Osteonecrosis de los maxilares asociada al empleo de bifosfonatos" @default.
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- W2046158815 doi "https://doi.org/10.4321/s1130-05582007000500001" @default.
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