Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046158926> ?p ?o ?g. }
- W2046158926 endingPage "35" @default.
- W2046158926 startingPage "1" @default.
- W2046158926 abstract "It was long thought that the prototypical centrally acting antihypertensive drug clonidine lowers sympathetic tone by activating alpha(2)-adrenoceptors in the brain stem. Supported by the development of two new centrally acting drugs, rilmenidine and moxonidine, the imidazoline hypothesis evolved recently. It assumes the existence of a new group of receptors, the imidazoline receptors, and attributes the sympathoinhibition to activation of I(1) imidazoline receptors in the medulla oblongata. This review analyzes the mechanism of action of clonidine-like drugs, with special attention given to the imidazoline hypothesis. Two conclusions are drawn. The first is that the arguments against the imidazoline hypothesis outweigh the observations that support it and that the sympathoinhibitory effects of clonidine-like drugs are best explained by activation of alpha(2)-adrenoceptors. The second conclusion is that this class of drugs lowers sympathetic tone not only by a primary action in cardiovascular regulatory centres in the medulla oblongata. Peripheral presynaptic inhibition of transmitter release from postganglionic sympathetic neurons contributes to the overall sympathoinhibition." @default.
- W2046158926 created "2016-06-24" @default.
- W2046158926 creator A5019565160 @default.
- W2046158926 date "2002-01-01" @default.
- W2046158926 modified "2023-10-17" @default.
- W2046158926 title "Imidazoline antihypertensive drugs: a critical review on their mechanism of action" @default.
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