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- W2046159507 abstract "A design strategy to convert a dual-binding site AChE inhibitor into triple functional compounds with promising in vitro profile against multifactorial syndromes, such as Alzheimer’s disease, is proposed. The lead compound bis(7)-tacrine (2) was properly modified to confer to the new molecules the ability of chelating metals, involved in the neurodegenerative process. The multifunctional compounds show activity against human AChE, are able to inhibit the AChE-induced amyloid-β aggregation, and chelate metals, such as iron and copper." @default.
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- W2046159507 date "2007-11-30" @default.
- W2046159507 modified "2023-09-29" @default.
- W2046159507 title "Multi-Target-Directed Drug Design Strategy: From a Dual Binding Site Acetylcholinesterase Inhibitor to a Trifunctional Compound against Alzheimer’s Disease" @default.
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- W2046159507 doi "https://doi.org/10.1021/jm701225u" @default.
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