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• W2046166661 startingPage "096012" @default.
• W2046166661 abstract "Diffuse optical tomography (DOT) is a noninvasive, nonionizing imaging modality that uses near-infrared light to visualize optically relevant chromophores. A recently developed dynamic DOT imaging system enables the study of hemodynamic effects in the breast during a breath-hold. Dynamic DOT imaging was performed in a total of 21 subjects (age 54±10 years ) including 3 healthy subjects and 18 subjects with benign (n=8 ) and malignant (n=14 ) masses. Three-dimensional time-series images of the percentage change in oxygenated and deoxygenated hemoglobin concentrations ([HbO 2 ] and [Hb]) from baseline are obtained over the course of a breath-hold. At a time point of 15 s following the end of the breath-hold, [Hb] in healthy breasts has returned to near-baseline values (1.6%±0.5% ), while tumor-bearing breasts have increased levels of [Hb] (6.8%±3.6% , p<0.01 ). Further, healthy subjects have a higher correlation between the breasts over the course of the breath-hold as compared with the subjects with breast cancer (healthy: 0.96±0.02 ; benign: 0.89±0.02 ; malignant: 0.78±0.23 , p<0.05 ). Therefore this study shows that dynamic features extracted from DOT measurements can differentiate healthy and diseased breast tissues. These features provide a physiologic method for identifying breast cancer without the need for ionizing radiation." @default.
• W2046166661 created "2016-06-24" @default.
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• W2046166661 date "2013-09-18" @default.
• W2046166661 modified "2023-09-27" @default.
• W2046166661 title "Optical biomarkers for breast cancer derived from dynamic diffuse optical tomography" @default.
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• W2046166661 doi "https://doi.org/10.1117/1.jbo.18.9.096012" @default.
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