FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046176321> ?p ?o ?g. }

• W2046176321 endingPage "112" @default.
• W2046176321 startingPage "106" @default.
• W2046176321 abstract "Background.The TOPAS (thrombolysis or peripheral artery surgery) trial randomized 544 patients with acute lower extremity ischemia to either surgery or thrombolysis. Although statistically equivalent 1-year morbidities and mortalities were demonstrated, the comparative cost-effectiveness of these two interventions has not been explored. Materials and methods.We constructed a Markov decision-analytic model to determine the cost-effectiveness of thrombolysis relative to surgery for a hypothetical cohort of patients with acute lower extremity arterial occlusion. Our measure of outcome was the cost-effectiveness ratio (CER), defined as the incremental lifetime cost per quality-adjusted life year gained. Estimates of 1-year outcomes were based on the TOPAS trial: mortality (lysis, 20%; surgery, 17%), amputation (lysis, 15%; surgery, 13%), the number of additional interventions required following the initial procedure (lysis, 544; surgery, 439). Procedural costs were estimated from the cost accounting system at the New York Presbyterian Hospital as well as from the literature. Results.Operative intervention for acute lower extremity arterial occlusion extended life and was less costly compared to thrombolysis. The projected life expectancy for patients who underwent initial surgery was 5.04 years versus 4.75 years for initial thrombolysis. The lifetime costs were $57,429 for surgery versus $dollar;76,326 for thrombolysis. In performing sensitivity analyses, a threshold CER of $60,000 was considered what society would pay for accepted medical interventions. Thrombolysis became cost-effective if the 1-year mortality rate for lysis was lowered from 20 to 10.7%, if the amputation rate for lysis diminished from 15 to 3.9%, or if the 1-year cost of lysis could be reduced to a level below $13,000. Conclusions.Initial surgery provides the most efficient and economical utilization of resources for acute lower extremity arterial occlusion. The high cost of thrombolysis is related to the expense of the lytic agents, the need for subsequent interventions in patients treated with initial lysis, and the long-term costs of amputation in patients who fail lytic therapy." @default.
• W2046176321 created "2016-06-24" @default.
• W2046176321 creator A5012140656 @default.
• W2046176321 creator A5021050696 @default.
• W2046176321 creator A5035820015 @default.
• W2046176321 creator A5053922415 @default.
• W2046176321 date "1999-05-01" @default.
• W2046176321 modified "2023-09-28" @default.
• W2046176321 title "Is Thrombolysis of Lower Extremity Acute Arterial Occlusion Cost-Effective?" @default.
• W2046176321 cites W1966547173 @default.
• W2046176321 cites W1968855271 @default.
• W2046176321 cites W1973214263 @default.
• W2046176321 cites W1989374461 @default.
• W2046176321 cites W2033338007 @default.
• W2046176321 cites W2045613591 @default.
• W2046176321 cites W2048611397 @default.
• W2046176321 cites W2063795466 @default.
• W2046176321 cites W2066776158 @default.
• W2046176321 cites W2076302875 @default.
• W2046176321 cites W2093245950 @default.
• W2046176321 cites W2105716674 @default.
• W2046176321 cites W2131001997 @default.
• W2046176321 cites W2147366252 @default.
• W2046176321 cites W2155601089 @default.
• W2046176321 cites W2164654252 @default.
• W2046176321 cites W2325910649 @default.
• W2046176321 doi "https://doi.org/10.1006/jsre.1999.5575" @default.
• W2046176321 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10329103" @default.
• W2046176321 hasPublicationYear "1999" @default.
• W2046176321 type Work @default.
• W2046176321 sameAs 2046176321 @default.
• W2046176321 citedByCount "16" @default.
• W2046176321 countsByYear W20461763212013 @default.
• W2046176321 countsByYear W20461763212018 @default.
• W2046176321 crossrefType "journal-article" @default.
• W2046176321 hasAuthorship W2046176321A5012140656 @default.
• W2046176321 hasAuthorship W2046176321A5021050696 @default.
• W2046176321 hasAuthorship W2046176321A5035820015 @default.
• W2046176321 hasAuthorship W2046176321A5053922415 @default.
• W2046176321 hasConcept C112930515 @default.
• W2046176321 hasConcept C118552586 @default.
• W2046176321 hasConcept C126322002 @default.
• W2046176321 hasConcept C133925201 @default.
• W2046176321 hasConcept C141071460 @default.
• W2046176321 hasConcept C168563851 @default.
• W2046176321 hasConcept C179755657 @default.
• W2046176321 hasConcept C194828623 @default.
• W2046176321 hasConcept C207103383 @default.
• W2046176321 hasConcept C27415008 @default.
• W2046176321 hasConcept C2776204877 @default.
• W2046176321 hasConcept C2776268601 @default.
• W2046176321 hasConcept C2779581417 @default.
• W2046176321 hasConcept C2908647359 @default.
• W2046176321 hasConcept C3019080777 @default.
• W2046176321 hasConcept C44249647 @default.
• W2046176321 hasConcept C500558357 @default.
• W2046176321 hasConcept C64332521 @default.
• W2046176321 hasConcept C71924100 @default.
• W2046176321 hasConcept C72563966 @default.
• W2046176321 hasConcept C99454951 @default.
• W2046176321 hasConceptScore W2046176321C112930515 @default.
• W2046176321 hasConceptScore W2046176321C118552586 @default.
• W2046176321 hasConceptScore W2046176321C126322002 @default.
• W2046176321 hasConceptScore W2046176321C133925201 @default.
• W2046176321 hasConceptScore W2046176321C141071460 @default.
• W2046176321 hasConceptScore W2046176321C168563851 @default.
• W2046176321 hasConceptScore W2046176321C179755657 @default.
• W2046176321 hasConceptScore W2046176321C194828623 @default.
• W2046176321 hasConceptScore W2046176321C207103383 @default.
• W2046176321 hasConceptScore W2046176321C27415008 @default.
• W2046176321 hasConceptScore W2046176321C2776204877 @default.
• W2046176321 hasConceptScore W2046176321C2776268601 @default.
• W2046176321 hasConceptScore W2046176321C2779581417 @default.
• W2046176321 hasConceptScore W2046176321C2908647359 @default.
• W2046176321 hasConceptScore W2046176321C3019080777 @default.
• W2046176321 hasConceptScore W2046176321C44249647 @default.
• W2046176321 hasConceptScore W2046176321C500558357 @default.
• W2046176321 hasConceptScore W2046176321C64332521 @default.
• W2046176321 hasConceptScore W2046176321C71924100 @default.
• W2046176321 hasConceptScore W2046176321C72563966 @default.
• W2046176321 hasConceptScore W2046176321C99454951 @default.
• W2046176321 hasIssue "2" @default.
• W2046176321 hasLocation W20461763211 @default.
• W2046176321 hasLocation W20461763212 @default.
• W2046176321 hasOpenAccess W2046176321 @default.
• W2046176321 hasPrimaryLocation W20461763211 @default.
• W2046176321 hasRelatedWork W1608938013 @default.
• W2046176321 hasRelatedWork W1987147490 @default.
• W2046176321 hasRelatedWork W2012720002 @default.
• W2046176321 hasRelatedWork W2037520776 @default.
• W2046176321 hasRelatedWork W2052781436 @default.
• W2046176321 hasRelatedWork W2108066954 @default.
• W2046176321 hasRelatedWork W2167051636 @default.
• W2046176321 hasRelatedWork W2366666323 @default.
• W2046176321 hasRelatedWork W2434740212 @default.
• W2046176321 hasRelatedWork W2528491780 @default.
• W2046176321 hasVolume "83" @default.
• W2046176321 isParatext "false" @default.

• next