Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046188214> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W2046188214 endingPage "16" @default.
- W2046188214 startingPage "16" @default.
- W2046188214 abstract "Enteropathy-associated T-cell lymphoma includes type I cases and distinctive type II cases that, according to 2008 and 2010 World Health Organization descriptions, are T-cell receptor β+. Although T-cell receptor γδ enteropathy-associated T-cell lymphomas are reported, it is unknown if they have distinctive features and if they should be categorized as enteropathy-associated T-cell lymphoma or as a mucocutaneous γδ T-cell lymphoma. To address these questions, the clinicopathologic, immunophenotypic, molecular, and cytogenetic features of 5 γδ-enteropathy-associated T-cell lymphomas were investigated. Only 1 patient had celiac disease and had type I enteropathy-associated T-cell lymphoma, and the others fulfilled the histopathologic criteria for type II enteropathy-associated T-cell lymphoma. All lacked cutaneous involvement. A celiac disease–associated HLA type was found in the patient with CD and one of four others. All were T-cell receptor γ+, T-cell receptor δ+, βF1−, CD3+, CD7+, CD5−, CD4−, and TIA-1+ with variable staining for CD2 (3/5), CD8 (2/5), Granzyme B (1/5), and CD56 (4/5). Fluorescence in situ hybridization demonstrated 9q34 gains in 4 cases, with 9q33-34 gains by single nucleotide polymorphism in 3 of these. Single nucleotide polymorphism analysis also demonstrated gains in 5q34-q35.1/5q35.1 (4/5), 8q24 (3/5), and in 32 other regions in 3 of 5 cases. Vδ1 rearrangements were identified in 4 of 4 cases with documented clonality showing the same clone in normal-appearing distant mucosa (3/3 tested cases). Thus, γδ-enteropathy-associated T-cell lymphomas share many features with other enteropathy-associated T-cell lymphoma and are mostly of type II. Their usual nonactivated cytotoxic phenotype and Vδ1 usage are features unlike many other mucocutaneous γδ T-cell lymphomas but shared with hepatosplenic T-cell lymphoma. These findings support the conclusion that a γδ T-cell origin at extracutaneous sites does not define a specific entity." @default.
- W2046188214 created "2016-06-24" @default.
- W2046188214 creator A5001237705 @default.
- W2046188214 creator A5010582324 @default.
- W2046188214 creator A5026532720 @default.
- W2046188214 creator A5029303870 @default.
- W2046188214 creator A5036008182 @default.
- W2046188214 creator A5046601855 @default.
- W2046188214 creator A5046867776 @default.
- W2046188214 creator A5050658579 @default.
- W2046188214 creator A5056138062 @default.
- W2046188214 date "2009-09-01" @default.
- W2046188214 modified "2023-09-26" @default.
- W2046188214 title "32LBA High level gene amplification of MYC characterizes radiation-induced angiosarcomas" @default.
- W2046188214 doi "https://doi.org/10.1016/s1359-6349(09)72067-1" @default.
- W2046188214 hasPublicationYear "2009" @default.
- W2046188214 type Work @default.
- W2046188214 sameAs 2046188214 @default.
- W2046188214 citedByCount "0" @default.
- W2046188214 crossrefType "journal-article" @default.
- W2046188214 hasAuthorship W2046188214A5001237705 @default.
- W2046188214 hasAuthorship W2046188214A5010582324 @default.
- W2046188214 hasAuthorship W2046188214A5026532720 @default.
- W2046188214 hasAuthorship W2046188214A5029303870 @default.
- W2046188214 hasAuthorship W2046188214A5036008182 @default.
- W2046188214 hasAuthorship W2046188214A5046601855 @default.
- W2046188214 hasAuthorship W2046188214A5046867776 @default.
- W2046188214 hasAuthorship W2046188214A5050658579 @default.
- W2046188214 hasAuthorship W2046188214A5056138062 @default.
- W2046188214 hasConcept C104317684 @default.
- W2046188214 hasConcept C113067387 @default.
- W2046188214 hasConcept C142724271 @default.
- W2046188214 hasConcept C2777542201 @default.
- W2046188214 hasConcept C2777589544 @default.
- W2046188214 hasConcept C2778426112 @default.
- W2046188214 hasConcept C2779134260 @default.
- W2046188214 hasConcept C2779338263 @default.
- W2046188214 hasConcept C2992511266 @default.
- W2046188214 hasConcept C30481170 @default.
- W2046188214 hasConcept C54355233 @default.
- W2046188214 hasConcept C71924100 @default.
- W2046188214 hasConcept C86803240 @default.
- W2046188214 hasConceptScore W2046188214C104317684 @default.
- W2046188214 hasConceptScore W2046188214C113067387 @default.
- W2046188214 hasConceptScore W2046188214C142724271 @default.
- W2046188214 hasConceptScore W2046188214C2777542201 @default.
- W2046188214 hasConceptScore W2046188214C2777589544 @default.
- W2046188214 hasConceptScore W2046188214C2778426112 @default.
- W2046188214 hasConceptScore W2046188214C2779134260 @default.
- W2046188214 hasConceptScore W2046188214C2779338263 @default.
- W2046188214 hasConceptScore W2046188214C2992511266 @default.
- W2046188214 hasConceptScore W2046188214C30481170 @default.
- W2046188214 hasConceptScore W2046188214C54355233 @default.
- W2046188214 hasConceptScore W2046188214C71924100 @default.
- W2046188214 hasConceptScore W2046188214C86803240 @default.
- W2046188214 hasIssue "3" @default.
- W2046188214 hasLocation W20461882141 @default.
- W2046188214 hasOpenAccess W2046188214 @default.
- W2046188214 hasPrimaryLocation W20461882141 @default.
- W2046188214 hasRelatedWork W137866725 @default.
- W2046188214 hasRelatedWork W1903361507 @default.
- W2046188214 hasRelatedWork W1975244825 @default.
- W2046188214 hasRelatedWork W1982122127 @default.
- W2046188214 hasRelatedWork W2012185993 @default.
- W2046188214 hasRelatedWork W2071559245 @default.
- W2046188214 hasRelatedWork W2085401660 @default.
- W2046188214 hasRelatedWork W2099625916 @default.
- W2046188214 hasRelatedWork W2170843351 @default.
- W2046188214 hasRelatedWork W4312847864 @default.
- W2046188214 hasVolume "7" @default.
- W2046188214 isParatext "false" @default.
- W2046188214 isRetracted "false" @default.
- W2046188214 magId "2046188214" @default.
- W2046188214 workType "article" @default.