FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046189675> ?p ?o ?g. }

• W2046189675 endingPage "9" @default.
• W2046189675 startingPage "9" @default.
• W2046189675 abstract "Current guidelines for managing ulcer bleeding state that patients with major stigmata should be managed by dual endoscopic therapy (injection with epinephrine plus a thermal or mechanical modality) followed by a high dose intravenous infusion of proton pump inhibitors (PPIs). This paper aims to review and critically evaluate evidence supporting the purported superiority of a continuous infusion over less intensive regimens of PPIs administration and the need for adding a second hemostatic endoscopic procedure to epinephrine injection. Systematic searches of PubMed, EMBASE and the Cochrane library were performed. There is strong evidence for an incremental benefit of PPIs over H2-receptor antagonists or placebo for the outcome of patients with peptic ulcer bleeding following endoscopic hemostasis. However, the benefit of PPIs is unrelated to either the dosage (intensive vs standard regimen) or the route of administration (intravenous vs oral). There is significant heterogeneity among the 15 studies that compared epinephrine with epinephrine plus a second modality, which might preclude the validity of reported summary estimates. Studies without second look endoscopy plus re-treatment of re-bleeding lesions showed a significant benefit of adding a second endoscopic modality for hemostasis, while studies with second-look and re-treatment showed equal efficacy between endoscopic mono and dual therapy. Inconclusive experimental evidence supports the current recommendation of the use of dual endoscopic hemostatic means and infusion of high-dose PPIs as standard therapy for patients with bleeding peptic ulcers. Presently, the combination of epinephrine monotherapy with standard doses of PPIs constitutes an appropriate treatment for the majority of patients." @default.
• W2046189675 created "2016-06-24" @default.
• W2046189675 creator A5015267957 @default.
• W2046189675 creator A5020815682 @default.
• W2046189675 creator A5038786804 @default.
• W2046189675 creator A5040818753 @default.
• W2046189675 creator A5069013780 @default.
• W2046189675 creator A5082451012 @default.
• W2046189675 date "2010-01-01" @default.
• W2046189675 modified "2023-09-24" @default.
• W2046189675 title "How evidence-based are current guidelines for managing patients with peptic ulcer bleeding?" @default.
• W2046189675 cites W1523681477 @default.
• W2046189675 cites W1527306622 @default.
• W2046189675 cites W1677765574 @default.
• W2046189675 cites W1964067924 @default.
• W2046189675 cites W1964314767 @default.
• W2046189675 cites W1969479858 @default.
• W2046189675 cites W1974574613 @default.
• W2046189675 cites W1981493121 @default.
• W2046189675 cites W1985273543 @default.
• W2046189675 cites W1988246529 @default.
• W2046189675 cites W1990175099 @default.
• W2046189675 cites W1994461011 @default.
• W2046189675 cites W1994865203 @default.
• W2046189675 cites W2022889473 @default.
• W2046189675 cites W2030793681 @default.
• W2046189675 cites W2032438896 @default.
• W2046189675 cites W2035563358 @default.
• W2046189675 cites W2038798915 @default.
• W2046189675 cites W2042710833 @default.
• W2046189675 cites W2048086356 @default.
• W2046189675 cites W2055029016 @default.
• W2046189675 cites W2068585347 @default.
• W2046189675 cites W2074697256 @default.
• W2046189675 cites W2080842912 @default.
• W2046189675 cites W2085477831 @default.
• W2046189675 cites W2085560449 @default.
• W2046189675 cites W2095219361 @default.
• W2046189675 cites W2111108353 @default.
• W2046189675 cites W2111489129 @default.
• W2046189675 cites W2121314908 @default.
• W2046189675 cites W2124374781 @default.
• W2046189675 cites W2126673014 @default.
• W2046189675 cites W2127095240 @default.
• W2046189675 cites W2131822964 @default.
• W2046189675 cites W2134773794 @default.
• W2046189675 cites W2140726930 @default.
• W2046189675 cites W2140732852 @default.
• W2046189675 cites W2140819427 @default.
• W2046189675 cites W2158435835 @default.
• W2046189675 cites W2162411651 @default.
• W2046189675 cites W3023580101 @default.
• W2046189675 cites W4252354669 @default.
• W2046189675 doi "https://doi.org/10.4240/wjgs.v2.i1.9" @default.
• W2046189675 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2999192" @default.
• W2046189675 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21160828" @default.
• W2046189675 hasPublicationYear "2010" @default.
• W2046189675 type Work @default.
• W2046189675 sameAs 2046189675 @default.
• W2046189675 citedByCount "1" @default.
• W2046189675 countsByYear W20461896752013 @default.
• W2046189675 crossrefType "journal-article" @default.
• W2046189675 hasAuthorship W2046189675A5015267957 @default.
• W2046189675 hasAuthorship W2046189675A5020815682 @default.
• W2046189675 hasAuthorship W2046189675A5038786804 @default.
• W2046189675 hasAuthorship W2046189675A5040818753 @default.
• W2046189675 hasAuthorship W2046189675A5069013780 @default.
• W2046189675 hasAuthorship W2046189675A5082451012 @default.
• W2046189675 hasBestOaLocation W20461896751 @default.
• W2046189675 hasConcept C126322002 @default.
• W2046189675 hasConcept C141071460 @default.
• W2046189675 hasConcept C142724271 @default.
• W2046189675 hasConcept C168563851 @default.
• W2046189675 hasConcept C204787440 @default.
• W2046189675 hasConcept C27081682 @default.
• W2046189675 hasConcept C2775859304 @default.
• W2046189675 hasConcept C2776345487 @default.
• W2046189675 hasConcept C2776478404 @default.
• W2046189675 hasConcept C2777628954 @default.
• W2046189675 hasConcept C2778451229 @default.
• W2046189675 hasConcept C2778589496 @default.
• W2046189675 hasConcept C2779390736 @default.
• W2046189675 hasConcept C2780656511 @default.
• W2046189675 hasConcept C2781413609 @default.
• W2046189675 hasConcept C42219234 @default.
• W2046189675 hasConcept C71924100 @default.
• W2046189675 hasConceptScore W2046189675C126322002 @default.
• W2046189675 hasConceptScore W2046189675C141071460 @default.
• W2046189675 hasConceptScore W2046189675C142724271 @default.
• W2046189675 hasConceptScore W2046189675C168563851 @default.
• W2046189675 hasConceptScore W2046189675C204787440 @default.
• W2046189675 hasConceptScore W2046189675C27081682 @default.
• W2046189675 hasConceptScore W2046189675C2775859304 @default.
• W2046189675 hasConceptScore W2046189675C2776345487 @default.
• W2046189675 hasConceptScore W2046189675C2776478404 @default.
• W2046189675 hasConceptScore W2046189675C2777628954 @default.
• W2046189675 hasConceptScore W2046189675C2778451229 @default.
• W2046189675 hasConceptScore W2046189675C2778589496 @default.

• next