FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046190304> ?p ?o ?g. }

• W2046190304 abstract "Cyclooxygenase (COX) products and pattern recognition receptors are important modulators of neuroinflammation; however, the role of prostaglandins and toll-like receptor (TLR) signaling and the functional crosstalk between COX modulators remains unclear, especially in astrocytes that closely modulate neuronal functions. Here, we studied the effect of prostaglandins on toll-like receptor 3 (TLR3)-induced cytokine expression in human astroglioma CRT-MG cells. Prostaglandin E2 (PGE2) was shown to increase cytosolic cAMP levels in an EP2 receptor dependent manner. Interestingly, the TLR3 agonist polyinosinic:polycytidylic acid (poly(I:C)) mediated phosphorylation of NF-κB and extracellular stress-related kinase 1/2 (ERK1/2), which significantly decreased following PGE2 treatment. In addition, PGE2 increased the phosphorylation and inactivation of glycogen synthesis kinase-3β (GSK-3β), whereas poly(I:C) decreased it. We observed that PGE2 decreased tumor necrosis factor-α (TNF-α) production evoked by poly(I:C), whereas PGE2 potentiated poly(I:C)-triggered interleukin-8 (IL-8) production. These results suggest that prostaglandin modulates the TLR3-mediated cytokine profile in astrocytes via EP2 receptors and regulates the NF-κB, ERK1/2 and GSK-3β signaling pathways." @default.
• W2046190304 created "2016-06-24" @default.
• W2046190304 creator A5003237492 @default.
• W2046190304 creator A5018376246 @default.
• W2046190304 creator A5018938074 @default.
• W2046190304 creator A5062738042 @default.
• W2046190304 creator A5063401549 @default.
• W2046190304 creator A5081834495 @default.
• W2046190304 date "2014-11-01" @default.
• W2046190304 modified "2023-10-17" @default.
• W2046190304 title "Prostaglandin modulates TLR3-induced cytokine expression in human astroglioma cells" @default.
• W2046190304 cites W1531467877 @default.
• W2046190304 cites W1553237709 @default.
• W2046190304 cites W1582815220 @default.
• W2046190304 cites W1935437386 @default.
• W2046190304 cites W1966751608 @default.
• W2046190304 cites W1968358948 @default.
• W2046190304 cites W1970184396 @default.
• W2046190304 cites W1975454216 @default.
• W2046190304 cites W1981764021 @default.
• W2046190304 cites W1995205013 @default.
• W2046190304 cites W2007913329 @default.
• W2046190304 cites W2010817360 @default.
• W2046190304 cites W2026321461 @default.
• W2046190304 cites W2033042047 @default.
• W2046190304 cites W2036364776 @default.
• W2046190304 cites W2042433863 @default.
• W2046190304 cites W2042681276 @default.
• W2046190304 cites W2046783872 @default.
• W2046190304 cites W2051947267 @default.
• W2046190304 cites W2054586855 @default.
• W2046190304 cites W2057042766 @default.
• W2046190304 cites W2057440510 @default.
• W2046190304 cites W2068004115 @default.
• W2046190304 cites W2069977126 @default.
• W2046190304 cites W2070620348 @default.
• W2046190304 cites W2076361525 @default.
• W2046190304 cites W2079320514 @default.
• W2046190304 cites W2084603524 @default.
• W2046190304 cites W2084740946 @default.
• W2046190304 cites W2111364165 @default.
• W2046190304 cites W2111464898 @default.
• W2046190304 cites W2121452718 @default.
• W2046190304 cites W2122873209 @default.
• W2046190304 cites W2125471714 @default.
• W2046190304 cites W2127621191 @default.
• W2046190304 cites W2129746956 @default.
• W2046190304 cites W2158960911 @default.
• W2046190304 cites W2164851792 @default.
• W2046190304 doi "https://doi.org/10.1016/j.brainres.2014.06.036" @default.
• W2046190304 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25014275" @default.
• W2046190304 hasPublicationYear "2014" @default.
• W2046190304 type Work @default.
• W2046190304 sameAs 2046190304 @default.
• W2046190304 citedByCount "5" @default.
• W2046190304 countsByYear W20461903042016 @default.
• W2046190304 countsByYear W20461903042017 @default.
• W2046190304 countsByYear W20461903042019 @default.
• W2046190304 countsByYear W20461903042021 @default.
• W2046190304 crossrefType "journal-article" @default.
• W2046190304 hasAuthorship W2046190304A5003237492 @default.
• W2046190304 hasAuthorship W2046190304A5018376246 @default.
• W2046190304 hasAuthorship W2046190304A5018938074 @default.
• W2046190304 hasAuthorship W2046190304A5062738042 @default.
• W2046190304 hasAuthorship W2046190304A5063401549 @default.
• W2046190304 hasAuthorship W2046190304A5081834495 @default.
• W2046190304 hasConcept C126322002 @default.
• W2046190304 hasConcept C134018914 @default.
• W2046190304 hasConcept C136449434 @default.
• W2046190304 hasConcept C170493617 @default.
• W2046190304 hasConcept C178592051 @default.
• W2046190304 hasConcept C185592680 @default.
• W2046190304 hasConcept C2776709828 @default.
• W2046190304 hasConcept C2776914184 @default.
• W2046190304 hasConcept C2777198256 @default.
• W2046190304 hasConcept C2778420691 @default.
• W2046190304 hasConcept C2778690821 @default.
• W2046190304 hasConcept C2778938600 @default.
• W2046190304 hasConcept C55493867 @default.
• W2046190304 hasConcept C62478195 @default.
• W2046190304 hasConcept C71924100 @default.
• W2046190304 hasConcept C86803240 @default.
• W2046190304 hasConcept C87753298 @default.
• W2046190304 hasConcept C95444343 @default.
• W2046190304 hasConceptScore W2046190304C126322002 @default.
• W2046190304 hasConceptScore W2046190304C134018914 @default.
• W2046190304 hasConceptScore W2046190304C136449434 @default.
• W2046190304 hasConceptScore W2046190304C170493617 @default.
• W2046190304 hasConceptScore W2046190304C178592051 @default.
• W2046190304 hasConceptScore W2046190304C185592680 @default.
• W2046190304 hasConceptScore W2046190304C2776709828 @default.
• W2046190304 hasConceptScore W2046190304C2776914184 @default.
• W2046190304 hasConceptScore W2046190304C2777198256 @default.
• W2046190304 hasConceptScore W2046190304C2778420691 @default.
• W2046190304 hasConceptScore W2046190304C2778690821 @default.
• W2046190304 hasConceptScore W2046190304C2778938600 @default.
• W2046190304 hasConceptScore W2046190304C55493867 @default.
• W2046190304 hasConceptScore W2046190304C62478195 @default.
• W2046190304 hasConceptScore W2046190304C71924100 @default.
• W2046190304 hasConceptScore W2046190304C86803240 @default.

• next