FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046193077> ?p ?o ?g. }

• W2046193077 endingPage "218" @default.
• W2046193077 startingPage "212" @default.
• W2046193077 abstract "Aripiprazole, a novel antipsychotic drug, is metabolized by CYP3A4 and CYP2D6 forming mainly its active metabolite dehydroaripiprazole. In this study, aripiprazole and dehydroaripiprazole serum levels of psychiatric patients were measured and related to dose, comedication, and clinical effects including therapeutic and side effects. Patients were treated with mean doses of 20±8 mg/day of aripiprazole (median 15 mg, range 7.5–60 mg). Serum levels correlated significantly with the dose (r=0.419; P<0.01), with a mean value of aripiprazole of 214±140 ng/ml. Mean concentrations of the active metabolite dehydroaripiprazole amounted to 40% of the parent compound. Comedication with CYP3A4 and CYP2D6 inducers or inhibitors changed serum levels up to 51%. Improvement was best in patients with a serum level between 150 to 300 ng/ml. No or only mild side effects were detected in patients, with aripiprazole plasma concentrations between 110 and 249 ng/ml. A total of 32% of the patients who received no other antipsychotic drug besides aripiprazole reported side effects; tension being the most frequent one. Since serum levels of aripiprazole and dehydroaripiprazole were highly variable between individuals, and distinct ranges were associated with good therapeutic response and minimal side effects, it seems likely that therapeutic drug monitoring can be helpful to improve the antipsychotic drug therapy." @default.
• W2046193077 created "2016-06-24" @default.
• W2046193077 creator A5002693421 @default.
• W2046193077 creator A5007740742 @default.
• W2046193077 creator A5014835551 @default.
• W2046193077 creator A5033140250 @default.
• W2046193077 creator A5052937172 @default.
• W2046193077 creator A5070582625 @default.
• W2046193077 creator A5078712231 @default.
• W2046193077 date "2008-01-01" @default.
• W2046193077 modified "2023-10-03" @default.
• W2046193077 title "Serum levels of aripiprazole and dehydroaripiprazole, clinical response and side effects" @default.
• W2046193077 cites W1971179661 @default.
• W2046193077 cites W2010741426 @default.
• W2046193077 cites W2011503104 @default.
• W2046193077 cites W2028730857 @default.
• W2046193077 cites W2030371995 @default.
• W2046193077 cites W2032712358 @default.
• W2046193077 cites W2037117401 @default.
• W2046193077 cites W2045058338 @default.
• W2046193077 cites W2050348372 @default.
• W2046193077 cites W2070357412 @default.
• W2046193077 cites W2070895158 @default.
• W2046193077 cites W2085999211 @default.
• W2046193077 cites W2098644261 @default.
• W2046193077 cites W2160406851 @default.
• W2046193077 cites W2160409159 @default.
• W2046193077 cites W4247120520 @default.
• W2046193077 doi "https://doi.org/10.1080/15622970701361255" @default.
• W2046193077 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17853280" @default.
• W2046193077 hasPublicationYear "2008" @default.
• W2046193077 type Work @default.
• W2046193077 sameAs 2046193077 @default.
• W2046193077 citedByCount "97" @default.
• W2046193077 countsByYear W20461930772012 @default.
• W2046193077 countsByYear W20461930772013 @default.
• W2046193077 countsByYear W20461930772014 @default.
• W2046193077 countsByYear W20461930772015 @default.
• W2046193077 countsByYear W20461930772016 @default.
• W2046193077 countsByYear W20461930772017 @default.
• W2046193077 countsByYear W20461930772018 @default.
• W2046193077 countsByYear W20461930772019 @default.
• W2046193077 countsByYear W20461930772020 @default.
• W2046193077 countsByYear W20461930772021 @default.
• W2046193077 countsByYear W20461930772022 @default.
• W2046193077 countsByYear W20461930772023 @default.
• W2046193077 crossrefType "journal-article" @default.
• W2046193077 hasAuthorship W2046193077A5002693421 @default.
• W2046193077 hasAuthorship W2046193077A5007740742 @default.
• W2046193077 hasAuthorship W2046193077A5014835551 @default.
• W2046193077 hasAuthorship W2046193077A5033140250 @default.
• W2046193077 hasAuthorship W2046193077A5052937172 @default.
• W2046193077 hasAuthorship W2046193077A5070582625 @default.
• W2046193077 hasAuthorship W2046193077A5078712231 @default.
• W2046193077 hasConcept C102652120 @default.
• W2046193077 hasConcept C109650736 @default.
• W2046193077 hasConcept C118552586 @default.
• W2046193077 hasConcept C126322002 @default.
• W2046193077 hasConcept C149151106 @default.
• W2046193077 hasConcept C19831878 @default.
• W2046193077 hasConcept C199360897 @default.
• W2046193077 hasConcept C2776412080 @default.
• W2046193077 hasConcept C2777477808 @default.
• W2046193077 hasConcept C2780035454 @default.
• W2046193077 hasConcept C2780211496 @default.
• W2046193077 hasConcept C2780272996 @default.
• W2046193077 hasConcept C2780494398 @default.
• W2046193077 hasConcept C33664856 @default.
• W2046193077 hasConcept C3454156 @default.
• W2046193077 hasConcept C41008148 @default.
• W2046193077 hasConcept C526171541 @default.
• W2046193077 hasConcept C62231903 @default.
• W2046193077 hasConcept C71924100 @default.
• W2046193077 hasConcept C98274493 @default.
• W2046193077 hasConceptScore W2046193077C102652120 @default.
• W2046193077 hasConceptScore W2046193077C109650736 @default.
• W2046193077 hasConceptScore W2046193077C118552586 @default.
• W2046193077 hasConceptScore W2046193077C126322002 @default.
• W2046193077 hasConceptScore W2046193077C149151106 @default.
• W2046193077 hasConceptScore W2046193077C19831878 @default.
• W2046193077 hasConceptScore W2046193077C199360897 @default.
• W2046193077 hasConceptScore W2046193077C2776412080 @default.
• W2046193077 hasConceptScore W2046193077C2777477808 @default.
• W2046193077 hasConceptScore W2046193077C2780035454 @default.
• W2046193077 hasConceptScore W2046193077C2780211496 @default.
• W2046193077 hasConceptScore W2046193077C2780272996 @default.
• W2046193077 hasConceptScore W2046193077C2780494398 @default.
• W2046193077 hasConceptScore W2046193077C33664856 @default.
• W2046193077 hasConceptScore W2046193077C3454156 @default.
• W2046193077 hasConceptScore W2046193077C41008148 @default.
• W2046193077 hasConceptScore W2046193077C526171541 @default.
• W2046193077 hasConceptScore W2046193077C62231903 @default.
• W2046193077 hasConceptScore W2046193077C71924100 @default.
• W2046193077 hasConceptScore W2046193077C98274493 @default.
• W2046193077 hasIssue "3" @default.
• W2046193077 hasLocation W20461930771 @default.
• W2046193077 hasLocation W20461930772 @default.
• W2046193077 hasOpenAccess W2046193077 @default.

• next