Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046199699> ?p ?o ?g. }
- W2046199699 endingPage "1736" @default.
- W2046199699 startingPage "1734" @default.
- W2046199699 abstract "Human cyclin-dependent kinase (CDK)-activating kinase (CAK) has a dual function in cross-regulation of cell cycle and differentiation, whereas menage a trois 1 (MAT1) assembles CAK and determines CAK's substrate specificity. Although the dynamic state of MAT1 protein levels is found to modulate CAK activity, how intracellular regulation of MAT1 controls CAK activity is unknown. Recent studies demonstrate that retinoic acid (RA)-induced human HL60 cell proliferation/differentiation (P/D) transition is accompanied by MAT1 degradation and decreased CAK phosphorylation of retinoic acid receptor alpha (RARa). Thus, we investigated the biochemical pathway of MAT1 degradation and its relationship with CAK phosphorylation of RARa. We find that RA induces ubiquitination-proteolysis of MAT1 and that ubiquitin-proteasome targets CAK-free MAT1 only. RA-induced MAT1 ubiquitination reduces CAK abundance and decreases CAK phosphorylation of RARalpha, whereas inhibition of MAT1 ubiquitination resists this RA-effect. These findings reveal that RA induces MAT1 ubiquitination to decrease CAK phosphorylation of RARalpha, suggesting a novel mechanism of RA-mediated P/D transition in which MAT1 ubiquitination may act as an integral part of RA-effect to decrease CAK activity in the switch from proliferation to differentiation." @default.
- W2046199699 created "2016-06-24" @default.
- W2046199699 creator A5020544186 @default.
- W2046199699 creator A5027469029 @default.
- W2046199699 creator A5030118440 @default.
- W2046199699 creator A5035648498 @default.
- W2046199699 creator A5081065929 @default.
- W2046199699 date "2004-09-02" @default.
- W2046199699 modified "2023-10-04" @default.
- W2046199699 title "Retinoid‐modulated MAT1 ubiquitination and CAK activity" @default.
- W2046199699 cites W126363341 @default.
- W2046199699 cites W131572820 @default.
- W2046199699 cites W1529813906 @default.
- W2046199699 cites W1553544241 @default.
- W2046199699 cites W1851733051 @default.
- W2046199699 cites W1909732837 @default.
- W2046199699 cites W1918570764 @default.
- W2046199699 cites W1943010247 @default.
- W2046199699 cites W1973985500 @default.
- W2046199699 cites W1976271397 @default.
- W2046199699 cites W1976687062 @default.
- W2046199699 cites W1978212420 @default.
- W2046199699 cites W1980049428 @default.
- W2046199699 cites W1982918697 @default.
- W2046199699 cites W1985134673 @default.
- W2046199699 cites W1986855081 @default.
- W2046199699 cites W1994066190 @default.
- W2046199699 cites W1999330214 @default.
- W2046199699 cites W2004431479 @default.
- W2046199699 cites W2008862713 @default.
- W2046199699 cites W2020294551 @default.
- W2046199699 cites W2027376766 @default.
- W2046199699 cites W2029080338 @default.
- W2046199699 cites W2029689941 @default.
- W2046199699 cites W2031134923 @default.
- W2046199699 cites W2051541258 @default.
- W2046199699 cites W2056403356 @default.
- W2046199699 cites W2064351475 @default.
- W2046199699 cites W2065252383 @default.
- W2046199699 cites W2066469256 @default.
- W2046199699 cites W2067989831 @default.
- W2046199699 cites W2070392447 @default.
- W2046199699 cites W2076217757 @default.
- W2046199699 cites W2080401826 @default.
- W2046199699 cites W2084163213 @default.
- W2046199699 cites W2087732988 @default.
- W2046199699 cites W2089865526 @default.
- W2046199699 cites W2091403769 @default.
- W2046199699 cites W2093467153 @default.
- W2046199699 cites W2099680656 @default.
- W2046199699 cites W2116320149 @default.
- W2046199699 cites W2122008851 @default.
- W2046199699 cites W2122508608 @default.
- W2046199699 cites W2136689951 @default.
- W2046199699 cites W2136776958 @default.
- W2046199699 cites W2140893763 @default.
- W2046199699 cites W2147921405 @default.
- W2046199699 cites W2153146045 @default.
- W2046199699 cites W2154503677 @default.
- W2046199699 cites W2162558360 @default.
- W2046199699 cites W4238997005 @default.
- W2046199699 doi "https://doi.org/10.1096/fj.04-2182fje" @default.
- W2046199699 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15345685" @default.
- W2046199699 hasPublicationYear "2004" @default.
- W2046199699 type Work @default.
- W2046199699 sameAs 2046199699 @default.
- W2046199699 citedByCount "14" @default.
- W2046199699 countsByYear W20461996992013 @default.
- W2046199699 countsByYear W20461996992014 @default.
- W2046199699 countsByYear W20461996992018 @default.
- W2046199699 countsByYear W20461996992019 @default.
- W2046199699 crossrefType "journal-article" @default.
- W2046199699 hasAuthorship W2046199699A5020544186 @default.
- W2046199699 hasAuthorship W2046199699A5027469029 @default.
- W2046199699 hasAuthorship W2046199699A5030118440 @default.
- W2046199699 hasAuthorship W2046199699A5035648498 @default.
- W2046199699 hasAuthorship W2046199699A5081065929 @default.
- W2046199699 hasConcept C104317684 @default.
- W2046199699 hasConcept C11960822 @default.
- W2046199699 hasConcept C184235292 @default.
- W2046199699 hasConcept C185592680 @default.
- W2046199699 hasConcept C25602115 @default.
- W2046199699 hasConcept C2781121885 @default.
- W2046199699 hasConcept C55493867 @default.
- W2046199699 hasConcept C86803240 @default.
- W2046199699 hasConcept C95444343 @default.
- W2046199699 hasConceptScore W2046199699C104317684 @default.
- W2046199699 hasConceptScore W2046199699C11960822 @default.
- W2046199699 hasConceptScore W2046199699C184235292 @default.
- W2046199699 hasConceptScore W2046199699C185592680 @default.
- W2046199699 hasConceptScore W2046199699C25602115 @default.
- W2046199699 hasConceptScore W2046199699C2781121885 @default.
- W2046199699 hasConceptScore W2046199699C55493867 @default.
- W2046199699 hasConceptScore W2046199699C86803240 @default.
- W2046199699 hasConceptScore W2046199699C95444343 @default.
- W2046199699 hasFunder F4320306095 @default.
- W2046199699 hasIssue "14" @default.
- W2046199699 hasLocation W20461996991 @default.