FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046200361> ?p ?o ?g. }

• W2046200361 endingPage "1686" @default.
• W2046200361 startingPage "1680" @default.
• W2046200361 abstract "ObjectiveNonlymphoma-associated bcl-2/IgH rearrangements (NLABRs) are frequently amplified by PCR in blood of lymphoma-free subjects (LFS), but the temporal kinetics and phenotypic nature of NLABR-positive cells are unknown. To address these issues we prospectively monitored a panel of NLABR-positive LFS.MethodsLFS have been studied by nested PCR, real-time PCR, and DNA sequencing. Cell selection studies were also performed to define the nature of NLABR-bearing clones.ResultsOf 125 donors, 16 (12.8%) were found to be bcl-2/IgH positive and were monitored at least every 6 months for a median time of 22 months (range 6–50). In half of the subjects the same NLABR detected initially was again reamplified at follow-up thrice or more. In 5, the same NLABR was constantly amplified in every follow-up sample. With a median follow-up of 22 months (range 9–50), no stable disappearance of a recurrent clone has been so far recorded. Real-time PCR indicated that persistent NLABR-positive clones are stable over time in the same subject. Cell separation studies indicate that NLABRs belong to CD19+, CD5−, CD23−, CD10+/− cells.ConclusionsOur results indicate that NLABR-positive clones are persistent populations phenotypically related to follicular lymphoma (FL). This suggests the existence of a FL-related clonal expansion of undetermined significance, which might be either a premalignant or a nonmalignant counterpart of FL. Nonlymphoma-associated bcl-2/IgH rearrangements (NLABRs) are frequently amplified by PCR in blood of lymphoma-free subjects (LFS), but the temporal kinetics and phenotypic nature of NLABR-positive cells are unknown. To address these issues we prospectively monitored a panel of NLABR-positive LFS. LFS have been studied by nested PCR, real-time PCR, and DNA sequencing. Cell selection studies were also performed to define the nature of NLABR-bearing clones. Of 125 donors, 16 (12.8%) were found to be bcl-2/IgH positive and were monitored at least every 6 months for a median time of 22 months (range 6–50). In half of the subjects the same NLABR detected initially was again reamplified at follow-up thrice or more. In 5, the same NLABR was constantly amplified in every follow-up sample. With a median follow-up of 22 months (range 9–50), no stable disappearance of a recurrent clone has been so far recorded. Real-time PCR indicated that persistent NLABR-positive clones are stable over time in the same subject. Cell separation studies indicate that NLABRs belong to CD19+, CD5−, CD23−, CD10+/− cells. Our results indicate that NLABR-positive clones are persistent populations phenotypically related to follicular lymphoma (FL). This suggests the existence of a FL-related clonal expansion of undetermined significance, which might be either a premalignant or a nonmalignant counterpart of FL." @default.
• W2046200361 created "2016-06-24" @default.
• W2046200361 creator A5005425076 @default.
• W2046200361 creator A5013522339 @default.
• W2046200361 creator A5014071526 @default.
• W2046200361 creator A5018139001 @default.
• W2046200361 creator A5021222227 @default.
• W2046200361 creator A5027144888 @default.
• W2046200361 creator A5030030391 @default.
• W2046200361 creator A5033110908 @default.
• W2046200361 creator A5036916107 @default.
• W2046200361 creator A5037246936 @default.
• W2046200361 creator A5048799921 @default.
• W2046200361 creator A5056141793 @default.
• W2046200361 creator A5058765211 @default.
• W2046200361 creator A5063136460 @default.
• W2046200361 creator A5076353357 @default.
• W2046200361 creator A5078287329 @default.
• W2046200361 creator A5079136601 @default.
• W2046200361 creator A5080599868 @default.
• W2046200361 creator A5087656442 @default.
• W2046200361 creator A5088712450 @default.
• W2046200361 creator A5090686439 @default.
• W2046200361 date "2006-12-01" @default.
• W2046200361 modified "2023-09-25" @default.
• W2046200361 title "Cells carrying nonlymphoma-associated bcl-2/IgH rearrangements (NLABR) are phenotypically related to follicular lymphoma and can establish as long-term persisting clonal populations" @default.
• W2046200361 cites W1495924730 @default.
• W2046200361 cites W1754056873 @default.
• W2046200361 cites W1984235497 @default.
• W2046200361 cites W1984534203 @default.
• W2046200361 cites W1986382133 @default.
• W2046200361 cites W1986500811 @default.
• W2046200361 cites W1987288688 @default.
• W2046200361 cites W1997493715 @default.
• W2046200361 cites W2011222606 @default.
• W2046200361 cites W2025216788 @default.
• W2046200361 cites W2025635508 @default.
• W2046200361 cites W2026296687 @default.
• W2046200361 cites W2034576012 @default.
• W2046200361 cites W2038221245 @default.
• W2046200361 cites W2041438500 @default.
• W2046200361 cites W2047480444 @default.
• W2046200361 cites W2056730769 @default.
• W2046200361 cites W2067603983 @default.
• W2046200361 cites W2067998415 @default.
• W2046200361 cites W2072954959 @default.
• W2046200361 cites W2104816759 @default.
• W2046200361 cites W2107202569 @default.
• W2046200361 cites W2115850463 @default.
• W2046200361 cites W2129818178 @default.
• W2046200361 cites W2134793460 @default.
• W2046200361 cites W2140322526 @default.
• W2046200361 cites W2164854559 @default.
• W2046200361 cites W2170635862 @default.
• W2046200361 cites W2208965687 @default.
• W2046200361 cites W2273653925 @default.
• W2046200361 cites W2321977289 @default.
• W2046200361 cites W2329386789 @default.
• W2046200361 cites W25693568 @default.
• W2046200361 cites W1988481255 @default.
• W2046200361 cites W2000655497 @default.
• W2046200361 doi "https://doi.org/10.1016/j.exphem.2006.08.008" @default.
• W2046200361 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17157165" @default.
• W2046200361 hasPublicationYear "2006" @default.
• W2046200361 type Work @default.
• W2046200361 sameAs 2046200361 @default.
• W2046200361 citedByCount "12" @default.
• W2046200361 countsByYear W20462003612012 @default.
• W2046200361 countsByYear W20462003612013 @default.
• W2046200361 countsByYear W20462003612014 @default.
• W2046200361 countsByYear W20462003612015 @default.
• W2046200361 countsByYear W20462003612017 @default.
• W2046200361 countsByYear W20462003612018 @default.
• W2046200361 countsByYear W20462003612019 @default.
• W2046200361 crossrefType "journal-article" @default.
• W2046200361 hasAuthorship W2046200361A5005425076 @default.
• W2046200361 hasAuthorship W2046200361A5013522339 @default.
• W2046200361 hasAuthorship W2046200361A5014071526 @default.
• W2046200361 hasAuthorship W2046200361A5018139001 @default.
• W2046200361 hasAuthorship W2046200361A5021222227 @default.
• W2046200361 hasAuthorship W2046200361A5027144888 @default.
• W2046200361 hasAuthorship W2046200361A5030030391 @default.
• W2046200361 hasAuthorship W2046200361A5033110908 @default.
• W2046200361 hasAuthorship W2046200361A5036916107 @default.
• W2046200361 hasAuthorship W2046200361A5037246936 @default.
• W2046200361 hasAuthorship W2046200361A5048799921 @default.
• W2046200361 hasAuthorship W2046200361A5056141793 @default.
• W2046200361 hasAuthorship W2046200361A5058765211 @default.
• W2046200361 hasAuthorship W2046200361A5063136460 @default.
• W2046200361 hasAuthorship W2046200361A5076353357 @default.
• W2046200361 hasAuthorship W2046200361A5078287329 @default.
• W2046200361 hasAuthorship W2046200361A5079136601 @default.
• W2046200361 hasAuthorship W2046200361A5080599868 @default.
• W2046200361 hasAuthorship W2046200361A5087656442 @default.
• W2046200361 hasAuthorship W2046200361A5088712450 @default.
• W2046200361 hasAuthorship W2046200361A5090686439 @default.
• W2046200361 hasBestOaLocation W20462003611 @default.
• W2046200361 hasConcept C104317684 @default.

• next