FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046200797> ?p ?o ?g. }

• W2046200797 endingPage "68" @default.
• W2046200797 startingPage "62" @default.
• W2046200797 abstract "A 30-kilodalton (kDa) proteinase from the house dust mite Dermatophagoides farinae (Df-proteinase) was recently purified (Takahashi et al. (1990) Int. Arch. Allergy Appl. Immunol. 91, 80–85). In this paper we detailed the biological activities of the Df-proteinase. The activation of the kinin cascade by Df-proteinase was examined in vitro by using purified guinea pig Hageman factor (HF), prekallikrein (PK) and high-molecular-weight kininogen (HMWK) and the effect of this proteinase on endogenous human plasma proteinase inhibitors (serpins) and α2-macroglobulin was tested. In addition, enhancement of the vascular permeability reaction in guinea pig skin by Df-proteinase was examined in vivo. These experiments showed that Df-proteinase could activate all the steps of the kinin-generating cascade, i.e., HF, PK and HMWK, and that Df-proteinase retained proteolytic activity even in the presence of an excess amount of endogenous proteinase inhibitors in plasma. We also found that the marked enhancement of the vascular permeability reaction was induced by Df-proteinase via the activation of the kinin-generating cascade without the release of histamine. From these results, we conclude that the proteinase of the house dust mite, Df-proteinase, has the potential to generate bradykinin and that the presence of this proteinase in biological systems would exacerbate inflammatory reactions in some pathological conditions." @default.
• W2046200797 created "2016-06-24" @default.
• W2046200797 creator A5009497595 @default.
• W2046200797 creator A5013562821 @default.
• W2046200797 creator A5029187625 @default.
• W2046200797 creator A5072183453 @default.
• W2046200797 creator A5080816054 @default.
• W2046200797 creator A5082596232 @default.
• W2046200797 creator A5087936762 @default.
• W2046200797 creator A5090091260 @default.
• W2046200797 date "1991-05-01" @default.
• W2046200797 modified "2023-10-18" @default.
• W2046200797 title "Triggering of the vascular permeability reaction by activation of the Hageman factor-prekallikrein system by house dust mite proteinase" @default.
• W2046200797 cites W1558653051 @default.
• W2046200797 cites W1632031335 @default.
• W2046200797 cites W1772080102 @default.
• W2046200797 cites W1818048824 @default.
• W2046200797 cites W1907959623 @default.
• W2046200797 cites W1923118929 @default.
• W2046200797 cites W1994517550 @default.
• W2046200797 cites W1996872037 @default.
• W2046200797 cites W2008549269 @default.
• W2046200797 cites W2008838733 @default.
• W2046200797 cites W2013409125 @default.
• W2046200797 cites W2015097614 @default.
• W2046200797 cites W2021416945 @default.
• W2046200797 cites W2026040177 @default.
• W2046200797 cites W2034766013 @default.
• W2046200797 cites W2036212754 @default.
• W2046200797 cites W2038226520 @default.
• W2046200797 cites W2067518324 @default.
• W2046200797 cites W2088598503 @default.
• W2046200797 cites W2090238133 @default.
• W2046200797 cites W2093001311 @default.
• W2046200797 cites W2134889315 @default.
• W2046200797 cites W2137391369 @default.
• W2046200797 cites W2141092325 @default.
• W2046200797 cites W2143776190 @default.
• W2046200797 cites W2160309830 @default.
• W2046200797 cites W2164422083 @default.
• W2046200797 cites W2434376181 @default.
• W2046200797 doi "https://doi.org/10.1016/0304-4165(91)90040-n" @default.
• W2046200797 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2043681" @default.
• W2046200797 hasPublicationYear "1991" @default.
• W2046200797 type Work @default.
• W2046200797 sameAs 2046200797 @default.
• W2046200797 citedByCount "33" @default.
• W2046200797 countsByYear W20462007972012 @default.
• W2046200797 countsByYear W20462007972013 @default.
• W2046200797 countsByYear W20462007972017 @default.
• W2046200797 countsByYear W20462007972018 @default.
• W2046200797 countsByYear W20462007972019 @default.
• W2046200797 crossrefType "journal-article" @default.
• W2046200797 hasAuthorship W2046200797A5009497595 @default.
• W2046200797 hasAuthorship W2046200797A5013562821 @default.
• W2046200797 hasAuthorship W2046200797A5029187625 @default.
• W2046200797 hasAuthorship W2046200797A5072183453 @default.
• W2046200797 hasAuthorship W2046200797A5080816054 @default.
• W2046200797 hasAuthorship W2046200797A5082596232 @default.
• W2046200797 hasAuthorship W2046200797A5087936762 @default.
• W2046200797 hasAuthorship W2046200797A5090091260 @default.
• W2046200797 hasConcept C1122143 @default.
• W2046200797 hasConcept C126322002 @default.
• W2046200797 hasConcept C134018914 @default.
• W2046200797 hasConcept C152328610 @default.
• W2046200797 hasConcept C170493617 @default.
• W2046200797 hasConcept C181199279 @default.
• W2046200797 hasConcept C185592680 @default.
• W2046200797 hasConcept C203014093 @default.
• W2046200797 hasConcept C203565725 @default.
• W2046200797 hasConcept C21194631 @default.
• W2046200797 hasConcept C2776246183 @default.
• W2046200797 hasConcept C2776914184 @default.
• W2046200797 hasConcept C2777167447 @default.
• W2046200797 hasConcept C2777902427 @default.
• W2046200797 hasConcept C2778382381 @default.
• W2046200797 hasConcept C2778815084 @default.
• W2046200797 hasConcept C2779591629 @default.
• W2046200797 hasConcept C52853521 @default.
• W2046200797 hasConcept C55493867 @default.
• W2046200797 hasConcept C71924100 @default.
• W2046200797 hasConcept C86803240 @default.
• W2046200797 hasConceptScore W2046200797C1122143 @default.
• W2046200797 hasConceptScore W2046200797C126322002 @default.
• W2046200797 hasConceptScore W2046200797C134018914 @default.
• W2046200797 hasConceptScore W2046200797C152328610 @default.
• W2046200797 hasConceptScore W2046200797C170493617 @default.
• W2046200797 hasConceptScore W2046200797C181199279 @default.
• W2046200797 hasConceptScore W2046200797C185592680 @default.
• W2046200797 hasConceptScore W2046200797C203014093 @default.
• W2046200797 hasConceptScore W2046200797C203565725 @default.
• W2046200797 hasConceptScore W2046200797C21194631 @default.
• W2046200797 hasConceptScore W2046200797C2776246183 @default.
• W2046200797 hasConceptScore W2046200797C2776914184 @default.
• W2046200797 hasConceptScore W2046200797C2777167447 @default.
• W2046200797 hasConceptScore W2046200797C2777902427 @default.
• W2046200797 hasConceptScore W2046200797C2778382381 @default.
• W2046200797 hasConceptScore W2046200797C2778815084 @default.

• next