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• W2046202036 abstract "ASA II–III patients, scheduled for peripheral vascular surgery, were included in a study designed to assess the effect of spinal epinephrine and clonidine on plasma concentrations of spinally administered 0.5% glucose-free bupivacaine. Patients were allocated randomly to three groups to receive via a spinal catheter 22.5 mg (4.5 ml) of bupivacaine alone (Group B, 9 patients) or combined with 0.3 mg epinephrine (Group BE, 10 patients) or 0.15 mg clonidine (Group BC, 10 patients). Sensory blockade was assessed by pin-prick and motor blockade on the Bromage scale. Bupivacaine plasma concentrations were measured by gas chromatography. A trend to prolongation of local anaesthetic blockade was documented in patients receiving bupivacaine plus epinephrine or clonidine. (Time to regression of sensory blockade to L2: 170 ± 75 min in Group B, 230 ± 50 min in Group BE, 232 ± 64 min in Group BC.) The maximum peak concentration (Cmax), the time to reach Cmax (Tmax) and the time-concentration curve from 0–180 min (AUC) were not different for the three groups (Cmax 228 ± 112 ng · ml-1 in Group B, 215 ± 103 ng · ml-1 in Group BE, 234 ± 159 ng · ml-1 in Group BC; Tmax 41 ± 34 min in Group B, 59 ± 31 min in Group BE, 68 ± 32 min in Group BC; AUC 31.0 ± 1.7 mg · ml-1 · min-1 in Group B, 27.3 ± 1.1 mg · ml-1 · min-1 in Group BE, 27.0 ± 1.1 mg · ml-1 · min-1 in Group BC). The results of this study suggest that epinephrine and clonidine do not decrease blood resorption of spinal bupivacaine." @default.
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• W2046202036 date "1992-10-01" @default.
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• W2046202036 title "Effects of epinephrine and clonidine on plasma concentrations of spinal bupivacaine" @default.
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• W2046202036 doi "https://doi.org/10.1111/j.1399-6576.1992.tb03544.x" @default.
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