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- W2046206722 endingPage "277" @default.
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- W2046206722 abstract "Strong evidence suggests that TNF-alpha may be among the chemical factors involved in disk-related sciatica. TNF-alpha is involved in the genesis of nerve pain in animal models and may promote pain-signal production from nerve roots previously subjected to mechanical deformation. In animal experiments, TNF-alpha has been identified in nucleus pulposus and Schwann cells. Local production of endogenous TNF-alpha may occur early in the pathogenic process. Exposure to exogenous TNF-alpha induces electrophysiological, histological, and behavioral changes similar to those seen after exposure to nucleus pulposus, and these changes are more severe when mechanical compression is applied concomitantly. TNF-alpha antagonists diminish or abolish abnormalities in animal models. Other cytokines may be involved also, as suggested by the potent inhibitory effects of compounds such as doxycycline. Two open-label studies in humans suggest dramatic efficacy of TNF-alpha antagonists in alleviating disk-related sciatica. In contrast, the results of the only controlled study available to date do not support a therapeutic effect of TNF-alpha antagonists. Thus, whether TNF-alpha antagonist therapy is warranted in patients with disk-related sciatica remains an open question, and further randomized controlled studies are needed." @default.
- W2046206722 created "2016-06-24" @default.
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- W2046206722 date "2006-05-01" @default.
- W2046206722 modified "2023-10-14" @default.
- W2046206722 title "Pathophysiology of disk-related low back pain and sciatica. II. Evidence supporting treatment with TNF-α antagonists" @default.
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- W2046206722 doi "https://doi.org/10.1016/j.jbspin.2005.03.004" @default.
- W2046206722 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16046171" @default.
- W2046206722 hasPublicationYear "2006" @default.
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