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- W2046211110 abstract "The effects of different concentrations of N-methylpyridinium-2-aldoxime methane sulphonate (P2S) on the neuromuscular block produced by methylisopropoxyphosphoryl fluoride (sarin), methylisopropoxy-(2-dimethylaminoethylthio)-phosphine oxide (37 S-N) and methylisopropoxyphosphoryl thiocholine (37 S-N+) have been studied. The block produced by the three inhibitors on the rat phrenic nerve diaphragm preparation is reversed by 1 × 10−5 M P2S. The time required to produce 50 per cent reversal of the block was the same against all inhibitors. In anaesthetized cats poisoned with lethal doses of 37 S-N+ plasma concentrations of about 2 × 10−5 M (4 μg/ml) were needed to counteract neuromuscular block, bradycardia, hypotension and respiratory failure." @default.
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- W2046211110 title "Minimum concentrations of N-methylpyridinium-2-aldoxime methane sulphonate (P2S) which reverse neuromuscular block" @default.
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- W2046211110 doi "https://doi.org/10.1016/0006-2952(61)90059-4" @default.
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