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- W2046216084 abstract "Direct measurement of surface forces has been employed for the systematic determination of interaction forces between nucleic acid base monolayers at various pH values from 5.6 to 9.3. Measured forces have been classified as (1) forces at a distance D > 20 nm, which are attractive or repulsive depending on the hydrophobicity and the charge of the surfaces and which can be accounted for in terms of the sum of “double-layer forces” and so-called “very long ranged hydrophobic attraction”; (2) forces at D < 20 nm, which are always attractive; and (3) pull-off (adhesive) forces from contact, which reflect characteristics of molecular contact between monolayers of nucleic acid bases. The forces between complementary pairs (adenine−thymine) are found, for the first time, to be always attractive and stable independently of separation distances as well as pH's studied. On the other hand, interactions between noncomplementary pairs (thymine−thymine, adenine−adenine) are found to be regulated by the surface charge; ..." @default.
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- W2046216084 date "1996-01-01" @default.
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- W2046216084 title "Direct Demonstration of Attraction for a Complementary Pair of Apposed Nucleic Acid Base Monolayers" @default.
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- W2046216084 doi "https://doi.org/10.1021/la950867o" @default.
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