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- W2046222132 abstract "Electrophoretic mobility and contact angle measurements have been made on alatrofloxacin mesylate and its formulations which were protected from or exposed to light, and its degradation product compound (F). In aqueous solution, the light-protected alatrofloxacin mesylate had a zeta-potential of +19 mV, a negligible electron-acceptor (γi+) surface tension parameter and an electron-donor surface tension parameter γi−=32.5 mJ m−2, which was higher than that of water. This caused the particles to be very hydrophilic and to form very stable suspensions in aqueous solution due, mainly, to a net Lewis acid–base (polar) repulsion. After the suspensions were exposed to light, the zeta-potential of the degradation product increassed to +37.8 mV, but the electron-donor surface tension parameter decreased to γi−=8 mJ m−2, making the molecules or particles very hydrophobic and causing them to flocculate. The energies of attraction in the latter case were mainly hydrophobic (90%) with about 10% resulting from van der Waals forces." @default.
- W2046222132 created "2016-06-24" @default.
- W2046222132 creator A5068395403 @default.
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- W2046222132 date "1999-08-01" @default.
- W2046222132 modified "2023-10-17" @default.
- W2046222132 title "Application of the extended DLVO theory—the stability of alatrofloxacin mesylate solutions" @default.
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- W2046222132 doi "https://doi.org/10.1016/s0927-7765(99)00024-7" @default.
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