FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046232010> ?p ?o ?g. }

• W2046232010 endingPage "314" @default.
• W2046232010 startingPage "308" @default.
• W2046232010 abstract "Though accurately evaluating the kinetics of release is critical for validating newly designed therapeutic carriers for in vivo applications, few methods yet exist for release measurement in real time and without the need for any sample preparation. Many of the current approaches (e.g. chromatographic methods, absorption spectroscopy, or NMR spectroscopy) rely on isolation of the released material from the loaded vehicles, which require additional sample purification and can lead to loss of accuracy when probing fast kinetics of release. In this study we describe the use of time-resolved fluorescence for in situ monitoring of small molecule release kinetics from biodegradable polymeric drug delivery systems. This method relies on the observation that fluorescent reporters being released from polymeric drug delivery systems possess distinct excited-state lifetime components, reflecting their different environments in the particle suspensions, i.e., confined in the polymer matrices or free in the aqueous environment. These distinct lifetimes enable real-time quantitative mapping of the relative concentrations of dye in each population to obtain precise and accurate temporal information on the release profile of particular carrier/payload combinations. We found that fluorescence lifetime better distinguishes subtle differences in release profiles (e.g. differences associated with dye loading) than conventional steady-state fluorescence measurements, which represent the averaged dye behavior over the entire scan. Given the method's applicability to both hydrophobic and hydrophilic cargo, it could be employed to model the release of any drug-carrier combination." @default.
• W2046232010 created "2016-06-24" @default.
• W2046232010 creator A5012210226 @default.
• W2046232010 creator A5027531597 @default.
• W2046232010 creator A5033955547 @default.
• W2046232010 creator A5047184312 @default.
• W2046232010 creator A5054591348 @default.
• W2046232010 date "2013-11-01" @default.
• W2046232010 modified "2023-09-25" @default.
• W2046232010 title "Application of time-resolved fluorescence for direct and continuous probing of release from polymeric delivery vehicles" @default.
• W2046232010 cites W1965875025 @default.
• W2046232010 cites W1977718036 @default.
• W2046232010 cites W1977887028 @default.
• W2046232010 cites W1983063610 @default.
• W2046232010 cites W1983299968 @default.
• W2046232010 cites W1995622462 @default.
• W2046232010 cites W1996998905 @default.
• W2046232010 cites W2006952113 @default.
• W2046232010 cites W2013019179 @default.
• W2046232010 cites W2014680165 @default.
• W2046232010 cites W2017985848 @default.
• W2046232010 cites W2019234680 @default.
• W2046232010 cites W2032760352 @default.
• W2046232010 cites W2036270692 @default.
• W2046232010 cites W2037818300 @default.
• W2046232010 cites W2048713359 @default.
• W2046232010 cites W2050207992 @default.
• W2046232010 cites W2066354221 @default.
• W2046232010 cites W2070445640 @default.
• W2046232010 cites W2077300098 @default.
• W2046232010 cites W2082136869 @default.
• W2046232010 cites W2082511916 @default.
• W2046232010 cites W2085446806 @default.
• W2046232010 cites W2087032263 @default.
• W2046232010 cites W2089773350 @default.
• W2046232010 cites W2090391132 @default.
• W2046232010 cites W2091684003 @default.
• W2046232010 cites W2092970481 @default.
• W2046232010 cites W2113123964 @default.
• W2046232010 cites W2116244282 @default.
• W2046232010 cites W2128978142 @default.
• W2046232010 cites W2152348616 @default.
• W2046232010 cites W2166842851 @default.
• W2046232010 cites W2321918222 @default.
• W2046232010 cites W2326787195 @default.
• W2046232010 cites W2416357582 @default.
• W2046232010 doi "https://doi.org/10.1016/j.jconrel.2013.06.018" @default.
• W2046232010 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3795917" @default.
• W2046232010 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23792808" @default.
• W2046232010 hasPublicationYear "2013" @default.
• W2046232010 type Work @default.
• W2046232010 sameAs 2046232010 @default.
• W2046232010 citedByCount "13" @default.
• W2046232010 countsByYear W20462320102013 @default.
• W2046232010 countsByYear W20462320102014 @default.
• W2046232010 countsByYear W20462320102015 @default.
• W2046232010 countsByYear W20462320102016 @default.
• W2046232010 countsByYear W20462320102017 @default.
• W2046232010 countsByYear W20462320102018 @default.
• W2046232010 countsByYear W20462320102019 @default.
• W2046232010 countsByYear W20462320102020 @default.
• W2046232010 crossrefType "journal-article" @default.
• W2046232010 hasAuthorship W2046232010A5012210226 @default.
• W2046232010 hasAuthorship W2046232010A5027531597 @default.
• W2046232010 hasAuthorship W2046232010A5033955547 @default.
• W2046232010 hasAuthorship W2046232010A5047184312 @default.
• W2046232010 hasAuthorship W2046232010A5054591348 @default.
• W2046232010 hasBestOaLocation W20462320102 @default.
• W2046232010 hasConcept C111368507 @default.
• W2046232010 hasConcept C121332964 @default.
• W2046232010 hasConcept C127313418 @default.
• W2046232010 hasConcept C127413603 @default.
• W2046232010 hasConcept C13245373 @default.
• W2046232010 hasConcept C144618238 @default.
• W2046232010 hasConcept C148898269 @default.
• W2046232010 hasConcept C158711907 @default.
• W2046232010 hasConcept C163588942 @default.
• W2046232010 hasConcept C171250308 @default.
• W2046232010 hasConcept C178790620 @default.
• W2046232010 hasConcept C185592680 @default.
• W2046232010 hasConcept C186060115 @default.
• W2046232010 hasConcept C192562407 @default.
• W2046232010 hasConcept C2777521759 @default.
• W2046232010 hasConcept C2778517922 @default.
• W2046232010 hasConcept C2779820397 @default.
• W2046232010 hasConcept C32909587 @default.
• W2046232010 hasConcept C42360764 @default.
• W2046232010 hasConcept C521977710 @default.
• W2046232010 hasConcept C62520636 @default.
• W2046232010 hasConcept C86803240 @default.
• W2046232010 hasConcept C91881484 @default.
• W2046232010 hasConceptScore W2046232010C111368507 @default.
• W2046232010 hasConceptScore W2046232010C121332964 @default.
• W2046232010 hasConceptScore W2046232010C127313418 @default.
• W2046232010 hasConceptScore W2046232010C127413603 @default.
• W2046232010 hasConceptScore W2046232010C13245373 @default.
• W2046232010 hasConceptScore W2046232010C144618238 @default.
• W2046232010 hasConceptScore W2046232010C148898269 @default.

• next